Immunomodulatory properties of porins of some members of the family Enterobacteriaceae.

Infection and Immunity
V Alurkar, R Kamat

Abstract

The outer membrane protein (OMP) preparation of Salmonella typhi was observed to have several immunomodulatory properties. Treatment of mice with an intraperitoneal injection of the OMP preparation enhanced both cellular and humoral responses of the mice to an unrelated antigen, a killed vaccine of Mycobacterium vaccae; both the delayed-type hypersensitivity (DTH) response and the antibody titers were enhanced. The predominant isotype of the antibody shifted from immunoglobulin G1 (IgG1) to IgG2a upon treatment with OMP. Treatment of mice with the OMP preparation improved the efficiency of in vitro antigen presentation by the peritoneal cells and also induced the cells to secrete interleukin-1. Treatment with the lipopolysaccharide (LPS) preparation of S. typhi had the opposite effect; i.e., the DTH response to M. vaccae was suppressed. Treatment with OMP neutralized the suppressive effects of LPS. The OMP preparation also had an enhancing effect on the innate immune mechanisms of the mice. Intraperitoneal injection of the OMP preparation enhanced the microbicidal activity of the peritoneal cells, and production of nitric oxide intermediates was stimulated. Injection of the OMP preparation into footpads of naive nonimmune mice ...Continue Reading

References

Jan 1, 1990·Critical Reviews in Microbiology·R Burrell
Oct 1, 1990·Infection and Immunity·F GaldieroM Di Rosa
Oct 1, 1991·Immunology Today·R P PhippsR L Roper
Feb 1, 1990·Clinical and Experimental Immunology·K E ShroffR S Kamat
Jan 1, 1986·Annual Review of Immunology·H S WarrenL A Chedid
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Oct 1, 1966·The Journal of Experimental Medicine·R V BlandenF M Collins
Jul 1, 1972·The Journal of Experimental Medicine·I GeryB H Waksman
May 1, 1982·Journal of Medical Microbiology·R Nair, R S Kamat
Jun 1, 1993·Immunology Today·F M Audibert, L D Lise
Jan 1, 1993·Infection and Immunity·F GaldieroM A Tufano
Jun 1, 1993·Immunology Today·J W Hadden
Jan 1, 1993·Annual Review of Immunology·F W FitchT F Gajewski
Sep 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·M J OSBORN

❮ Previous
Next ❯

Citations

Jun 24, 2004·Infection and Immunity·Kristina M Williams, Elmer C Bigley
Jul 15, 2005·Molecular and Cellular Biochemistry·Shaloo SoodNirmal Kumar Ganguly
Feb 26, 2013·Immunology·Mario A Moreno-EutimioConstantino López-Macías
May 25, 2012·Clinical and Vaccine Immunology : CVI·Deana N ToussiPaola Massari
Oct 8, 2013·PloS One·Denis LeclercPierre Savard
Oct 4, 2013·Microbiology·Sara SandriniPrimrose Freestone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.