Immunomorphological characteristics of human Peyer's patches

Digestion
P Brandtzaeg, K Bjerke

Abstract

Human follicle-associated epithelium (FAE) was found not to express the secretory component (SC) or polymeric immunoglobulin (pIg) receptor, and is therefore unable to transport pIgA to the gut lumen. However, human FAE (except the M cells) was positive for MHC class II (HLA-DR) determinants. It may therefore perform class II-restricted uptake and presentation to T cells of antigens that have been adequately processed, whereas the function of the M cells is perhaps limited to transport of particulate or undergraded luminal antigens to subjacent antigen-presenting cells (APC). A large number of APC of the inter-digitating cell phenotype (positive for HLA-DR and S-100 protein) and relatively few L1-positive reactive macrophages were found in PP between the follicles and beneath the FAE, compared with villous mucosa. Also, there were significantly more intra- and subepithelial T cells in PP than in distant villi, and the T cells were concentrated adjacent to the M cells. The proportion of the CD4+ subset (putative helper T cells) was much higher in FAE (40%) than in villous epithelium where the CD8+ subset (putative suppressor T cells) predominated strikingly (90%). This disparity might reflect differences in capacity for positive...Continue Reading

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