PMID: 639749Jan 1, 1978Paper

Immunomorphological studies of chronic hepatitis and liver cirrhosis

Eksperimentalna meditsina i morfologiia
M TsonevaG Kuvandzhiev

Abstract

The authors carried out clincial and immunomorphologic studies on 15 patients with chronic hepatitis and liver cirrhosis with unknown etiology. The presence of specific sensibilization of lymphocytes of the patients to liver tissue was examined by blast-transformation test. For this purpose they compared immunomorphologic response to lymphocytes in culture from peripheral blood to liver and renal antigen, using parallel procedure with FHA and cultures, growing spontaneously. Ten clinically healthy and 12 persons with renal polycystosis were examined as controls. The results showed an increased immune response to lymphocytes of the patient with liver cirrhosis to liver antigen as well as to culture, developing spontaneously, which suggested that autoimmune reaction with specific tendency to antigens of liver developed in these persons.

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.