Apr 17, 2019

Immunoneuropsychiatry - novel perspectives on brain disorders

Nature Reviews. Neurology
Katrin PapeFrauke Zipp


Immune processes have a vital role in CNS homeostasis, resilience and brain reserve. Our cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune responses that involve both innate and adaptive immunity. Autoimmunity, chronic inflammation, infection and psychosocial stress can tip the scales towards disruption of higher-order networks. However, not only classical neuroinflammatory diseases, such as multiple sclerosis and autoimmune encephalitis, are caused by immune dysregulation that affects CNS function. Recent insight indicates that similar processes are involved in psychiatric diseases such as schizophrenia, autism spectrum disorder, bipolar disorder and depression. Pathways that are common to these disorders include microglial activation, pro-inflammatory cytokines, molecular mimicry, anti-neuronal autoantibodies, self-reactive T cells and disturbance of the blood-brain barrier. These discoveries challenge our traditional classification of neurological and psychiatric diseases. New clinical paths are required to identify subgroups of neuropsychiatric disorders that are phenotypically distinct but pathogenically related and to pave the way for mechanism-based immune treatments. Combined...Continue Reading

  • References1
  • Citations6


Mentioned in this Paper

Immune Response
Brain Diseases
Inflammatory Disorder
Chronic Inflammation
Bipolar Disorder

Related Feeds


Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Richard M RansohoffAmit Bar-Or
Cellular and Molecular Life Sciences : CMLS
Adelaide FernandesTeresa F Pais
Frontiers in Cellular Neuroscience
Hansen Wang, Laurie C Doering
© 2020 Meta ULC. All rights reserved