Abstract
The purpose of this experiment was to examine directly whether inhibin is involved in the testicular regulation of FSH secretion in the male rhesus monkey. To this end, the pituitary-testicular axis in eight juvenile monkeys was prematurely activated by a chronic iv infusion of GnRH (0.1 microgram/min for 3 min every 3 h). After a minimum of 5 weeks of pulsatile GnRH stimulation, four animals received a brief (30-min) iv infusion of an ovine antiserum to inhibin alpha-subunit (approximately 10 ml/kg BW), and four monkeys received a comparable volume of a control ovine immune serum. The pulsatile GnRH infusion continued without interruption throughout the entire experiment. The FSH response to passive immunization against inhibin was determined by measuring concentrations of this gonadotropin in sequential plasma samples collected immediately before a GnRH infusion and for 3 h thereafter (an inter-GnRH pulse interval) on days 0.5, 1, 2, 4, 8, and 16 after injection of the immune serum. Administration of the antiserum to inhibin alpha-subunit resulted, within 2 days, in a 2- to 3-fold increase in the mean concentration and pulse amplitude of plasma FSH. The hypersecretion of FSH induced by administration of the antiserum to inhib...Continue Reading
Citations
Oct 1, 1992·Domestic Animal Endocrinology·A J TilbrookI J Clarke
Jan 1, 1994·Domestic Animal Endocrinology·J F RoserE Hoye
Aug 26, 1998·Vaccine·C R SewaniM Bagdasarian
Jul 14, 2001·Molecular and Cellular Endocrinology·S Ramaswamy, T M Plant
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·D M RobertsonD M de Kretser
Mar 1, 1993·Clinical Endocrinology·N LahlouA Warnet
Oct 31, 2009·The International Journal of Developmental Biology·Thaddeus G GolosMaureen Durning
Nov 7, 2003·Human Immunology·Thaddeus G Golos
Feb 1, 1994·Maturitas·M HajiH Nawata
May 18, 1999·Biology of Reproduction·J H BameJ J Ireland
Feb 24, 2001·Biology of Reproduction·A J Tilbrook, I J Clarke
Feb 13, 2001·Biology of Reproduction·A J TilbrookI J Clarke
Jul 29, 1998·Endocrinology·S RamaswamyT M Plant
Apr 1, 1997·Endocrinology·H G Burger, D M Robertson
Apr 1, 1997·Endocrinology·S S MajumdarT M Plant
Apr 24, 2019·Journal of Investigative Medicine High Impact Case Reports·Richard SantenAzeez Farooki
Aug 1, 1997·The Journal of Clinical Endocrinology and Metabolism·T M PlantA S McNeilly
Dec 1, 1999·Endocrinology·S J Winters, T M Plant
Mar 1, 1995·Archives of Andrology·S Saito