Immunoneutralization of procalcitonin or its component peptides: a promising treatment of sepsis

Clinical Science
Kenneth L Becker

Abstract

Sepsis and the severe systemic response syndrome are very common illnesses that are responsible for a great amount of morbidity and death. These closely related conditions are characterized by a remarkable increase in the prohormone ProCT (procalcitonin). ProCT is both a marker of sepsis and a harmful mediator of the disease. In the present issue of Clinical Science, in a study in rats with endotoxin shock, Tavares and Miñano used an antibody to a segment of N-ProCT (aminoprocalcitonin) that is part of the ProCT molecule, and confirmed that immunoneutralization of ProCT saves the animals from this severe illness. Furthermore, they extensively studied the epiphenomena associated with this immunoneutralization.

References

Mar 6, 2003·Critical Care : the Official Journal of the Critical Care Forum·Elizabeth SladeJean-Louis Vincent
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
May 19, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Gerald SteinbachGerhard Schumann
Jan 17, 2009·Pediatric Emergency Care·Muhammad Waseem, Michael R Kane
Jan 17, 2009·Pediatric Emergency Care·Glen Cheng, John R Bach
Oct 7, 2009·The Journal of Clinical Investigation·Kent DoiRobert A Star
Dec 17, 2009·British Journal of Pharmacology·Kenneth L BeckerEric S Nylen

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Citations

Nov 26, 2014·The Journal of Clinical Endocrinology and Metabolism·Zhaoyan ChenYingjun Suo
Oct 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Silvia AngelettiGiordano Dicuonzo

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