PMID: 9182877Jan 1, 1997Paper

Immunons revisited: binding of multivalent antigens to B cells

Molecular Immunology
B Sulzer, A S Perelson

Abstract

The T-independent B cell response induced by highly multivalent hapten polymer preparations has been studied extensively. The in vitro measured dose-response curve tends to be roughly bell-shaped with the peak response occurring at very low ligand concentrations, between 0.1-1 ng/ml for a variety of different ligands. Furthermore, polymers with more than approximately 10 haptens tend to be stimulatory, whereas polymers with fewer than 10 haptens conjugated, tend to be inhibitory. These observations have been perplexing when viewed within the context of standard theories of receptor ligation by multivalent ligands. We present a new analysis of these previous experiments that reconciles the differences between theory and experiment. From this theory it is concluded that the peak in the observed dose response curve only weakly reflects properties of the ligand and the affinity of surface immunoglobulin for the hapten, but depends strongly on the density of antigen-specific B cells in the culture. The number of responding cells decreases at low ligand concentrations, because cells have to share limiting amounts of ligand and not because of the decreasing probability of receptors and ligands meeting each other. Our theory leads to t...Continue Reading

References

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Jul 15, 1996·Mathematical Biosciences·B Sulzer, A S Perelson

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Citations

Sep 6, 2002·Journal of Immunological Methods·Tarek M FahmyJonathan P Schneck
Oct 6, 1998·Journal of Immunological Methods·S J Merrill
Oct 15, 2011·PLoS Computational Biology·Beata HatTomasz Lipniacki
Jul 14, 2010·PLoS Pathogens·Tamar CanelloRuth Gabizon
Feb 28, 2009·Pharmaceutical Research·Wim JiskootHuub Schellekens
Oct 20, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Timothy P HicklingSatyaprakash Nayak
Jun 28, 2012·Journal of Pharmaceutical Sciences·Dean C Ripple, Mariana N Dimitrova
May 2, 2012·International Journal of Pharmaceutics·Wei WangSandeep Nema
Mar 21, 2007·Immunological Reviews·Yoram Louzoun
Dec 19, 2015·Journal of Immunology Research·Liusong YinTimothy P Hickling
Nov 28, 2017·Frontiers in Microbiology·Carlos A Toro AcevedoSantuza M R Teixeira
Mar 25, 2006·Angewandte Chemie·Laura L KiesslingLaura E Strong
May 17, 2019·The Journal of Chemical Physics·Nicholas B Tito
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paula M BerguerFernando A Goldbaum
Jan 18, 2020·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Tine Curk, Nicholas B Tito

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