"Immunonutrition" Has Failed to Improve Peritonitis-Induced Septic Shock in Rodents

PloS One
Julie Boisramé-HelmsFerhat Meziani

Abstract

Immunonutrition in sepsis, including n-3 poly-unsaturated fatty acids (PUFAs) or L-arginine supplementation, is a controversial issue that has yielded a great number of studies for the last thirty-five years, and the conclusions regarding the quantity and quality of this support in patients are deceiving. The aim of the present experimental study is to investigate the effects of a pretreatment with enteral nutrition enriched with n-3 PUFAs or L-arginine on vascular dysfunctions, inflammation and oxidative stress during septic shock in rats. Rats were fed with enteral Peptamen® HN (HN group), Peptamen® AF containing n-3 PUFAs (AF group) or Peptamen® AF enriched with L-arginine (AFA group). On day 4, peritonitis by cecal ligation and puncture (CLP) was performed. Rats were resuscitated (H18) once septic shock was established. After a 4-hour resuscitation, vessels and organs were harvested to assess inflammation, superoxide anion, nitric oxide and prostacyclin levels. Ex-vivo vascular reactivity was also performed. Compared to CLP-AF or CLP-HN groups, 47.6% of CLP-AFA rats died before the beginning of hemodynamic measurements (vs. 8.0% and 20.0% respectively, p<0.05). AF and AFA rats required significantly increased norepinephrine...Continue Reading

References

Nov 1, 1979·Annals of Surgery·H FreundJ E Fischer
Dec 1, 1993·The American Review of Respiratory Disease·J G UmansP T Schumacker
Jan 13, 1998·Biochemical and Biophysical Research Communications·F AchardM Lagarde
Apr 6, 2001·JPEN. Journal of Parenteral and Enteral Nutrition·D K Heyland, F Novak
Dec 12, 2001·Cardiovascular Research·M Y Abeywardena, R J Head
May 19, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Stéphane VilletMette M Berger
Feb 18, 2006·Critical Care Medicine·Axel R HellerThea Koch
Sep 15, 2006·Critical Care Medicine·Andre C KalilRobert L Danner
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Apr 13, 2007·Intensive Care Medicine·Djamel HamaniChristophe Moinard
Sep 22, 2007·Critical Care Medicine·Adrian Barbul, Ajith Uliyargoli
Dec 6, 2008·The American Journal of Clinical Nutrition·Yvette C LuikingNicolaas E P Deutz
Dec 25, 2008·Clinical Science·Christina C KaoFarook Jahoor
Apr 16, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Djamel HamaniChristophe Moinard
Jul 7, 2010·Critical Care : the Official Journal of the Critical Care Forum·Matthias LangePerenlei Enkhbaatar
Jul 28, 2010·Molecular Endocrinology·W Edward VisserTheo J Visser
Dec 15, 2010·Critical Care Medicine·Joshua S Davis, Nicholas M Anstey
Jul 1, 2011·The New England Journal of Medicine·Michael P CasaerGreet Van den Berghe
Sep 3, 2011·European Journal of Clinical Investigation·Fatimazahra ElwafiChristophe Moinard
Jul 7, 2012·British Journal of Clinical Pharmacology·Philip C Calder
Jul 20, 2012·Critical Care Medicine·Luc CynoberChristine Charrueau
Mar 20, 2013·Current Vascular Pharmacology·Julie Boisramé-HelmsFerhat Meziani
Apr 20, 2013·Critical Care : the Official Journal of the Critical Care Forum·Undurti N Das
Mar 19, 2014·Journal of Lipid Research·Robert FischerWolf-Hagen Schunck
May 7, 2014·Chest·Svetang V DesaiTodd W Rice
Jun 18, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Clemens von Schacky
Oct 2, 2014·The New England Journal of Medicine·Sheila E HarveyUNKNOWN CALORIES Trial Investigators
Dec 5, 2014·World Review of Nutrition and Dietetics·Axel R Heller

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Citations

Jul 23, 2016·Mediators of Inflammation·Gustav van NiekerkAnna-Mart Engelbrecht
Sep 6, 2019·Nutrients·Candice Quin, Deanna L Gibson
Jan 18, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Fabiani L R BealOsmar N Silva

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Methods Mentioned

BETA
electron paramagnetic resonance
electrophoresis
ELISA

Software Mentioned

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