Immunopathogenesis of coronavirus infections: implications for SARS

Nature Reviews. Immunology
Stanley Perlman, Ajai A Dandekar

Abstract

At the end of 2002, the first cases of severe acute respiratory syndrome (SARS) were reported, and in the following year, SARS resulted in considerable mortality and morbidity worldwide. SARS is caused by a novel species of coronavirus (SARS-CoV) and is the most severe coronavirus-mediated human disease that has been described so far. On the basis of similarities with other coronavirus infections, SARS might, in part, be immune mediated. As discussed in this Review, studies of animals that are infected with other coronaviruses indicate that excessive and sometimes dysregulated responses by macrophages and other pro-inflammatory cells might be particularly important in the pathogenesis of disease that is caused by infection with these viruses. It is hoped that lessons from such studies will help us to understand more about the pathogenesis of SARS in humans and to prevent or control outbreaks of SARS in the future.

Associated Clinical Trials

Jan 25, 2021·Thomas Smoot, PharmD

References

May 1, 1973·Archives of Neurology·L P Weiner
Mar 30, 1973·Acta Neuropathologica·P W LampertA J Kniazeff
Jan 1, 1981·Comparative Immunology, Microbiology and Infectious Diseases·R C Weiss, F W Scott
Jan 1, 1993·The Veterinary Clinics of North America. Small Animal Practice·J D Hoskins
Dec 1, 1996·Journal of Virology·B L HaagmansM C Horzinek
Jun 13, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J O Hendley
Dec 5, 1998·Veterinary Immunology and Immunopathology·S PaltrinieriS Comazzi
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G F WuS Perlman
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M T LiuT E Lane
Jan 6, 2001·Brain Pathology·S A Stohlman, D R Hinton
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M T LiuT E Lane
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B P ChenT E Lane
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lecia Pewe, Stanley Perlman
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jodie S HaringStanley Perlman
May 16, 2003·Nature·Ron A M FouchierAlbert D M E Osterhaus
Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
Jun 21, 2003·BMJ : British Medical Journal·Raymond S M WongJoseph J Y Sung

❮ Previous
Next ❯

Citations

Sep 22, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Keiji KubaJosef M Penninger
Apr 20, 2006·Nature Immunology·Peter C DohertyPaul G Thomas
Jan 5, 2007·Nature Reviews. Microbiology·Kevin K AriënEric J Arts
May 12, 2009·Nature Reviews. Microbiology·Stanley Perlman, Jason Netland
Aug 31, 2006·Current Opinion in Infectious Diseases·Patrick Cy WooKwok-yung Yuen
Apr 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·John M Nicholls, J S Malik Peiris
Jul 16, 2010·Journal of Virology·Julian L LeibowitzSusan R Weiss
Sep 19, 2008·Journal of Virology·Andrew D Regan, Gary R Whittaker
Jan 25, 2007·Annual Review of Immunology·Jun Chen, Kanta Subbarao
Oct 24, 2007·Annual Review of Immunology·S M VidalP Gros
Jul 11, 2013·Clinical & Developmental Immunology·Andrew HiattKevin J Whaley
Sep 13, 2013·Journal of Virology·Daniela NiemeyerMarcel A Müller
Nov 2, 2011·The Veterinary Clinics of North America. Small Animal Practice·Yvonne DrechslerPedro Paulo V P Diniz
Nov 7, 2009·Clinics in Laboratory Medicine·Brigitte A Wevers, Lia van der Hoek
Sep 22, 2015·Plant Biotechnology Journal·Stephen J StreatfieldVidadi Yusibov
Mar 7, 2008·Cytokine & Growth Factor Reviews·Volker Thiel, Friedemann Weber
Jul 10, 2007·Research in Veterinary Science·V ZappulliM Castagnaro
May 23, 2014·Immunologic Research·Rudragouda ChannappanavarStanley Perlman

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Teruo Kirikae
Nihon Jibiinkoka Gakkai kaiho
Kazutoku Oishi
Connecticut Medicine
Dorothy Levine
Nature Reviews. Microbiology
B OlowokureJ S Mackenzie
© 2021 Meta ULC. All rights reserved