Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia

Autoimmunity Reviews
Alessandro AntonelliPoupak Fallahi

Abstract

Hepatitis C Virus (HCV) is known to be responsible for both hepatic and extrahepatic diseases (HCV-related extrahepatic diseases = HCV-EHDs). The most important systemic HCV-EHDs are mixed cryoglobulinemia and lymphoproliferative disorders, while the most frequent and clinically important endocrine HCV-EHDs are thyroid disorders and type 2 diabetes mellitus (T2D). From a meta-analysis of the literature a significant association between HCV infection and thyroid autoimmunity and hypothyroidism has been reported. A high prevalence of thyroid cancer has been reported, too. Furthermore, several clinical epidemiologic studies have reported that HCV infection is associated to T2D. Many studies have linked Th1 immune response with HCV infection, thyroid autoimmunity, or diabetes. These findings suggest that a possible common immunological Th1 pattern could be the pathophysiological base of the association of HCV-EHDs, with thyroid autoimmunity and T2D. In fact, HCV infection of thyrocytes or beta-cells may act by upregulating CXCL10 secretion in these cells that is responsible for Th1 lymphocyte recruitment. Th1 response leads to increased IFNgamma and TNFalpha production that in turn stimulates CXCL10 secretion by the target cells, t...Continue Reading

References

Jul 1, 1991·Reviews of Infectious Diseases·J R ArribasJ J Vazquez
Oct 1, 1994·British Journal of Haematology·C FerriA Mazzoni
Jun 1, 1997·Immunology Today·S Romagnani
Jul 15, 2000·Seminars in Liver Disease·E J Gowans
Sep 18, 2003·Rheumatology·A AntonelliE Ferrannini
Jun 24, 2004·The American Journal of Medicine·Alessandro AntonelliEle Ferrannini
Jul 17, 2004·QJM : Monthly Journal of the Association of Physicians·A AntonelliE Ferrannini
Nov 3, 2004·Autoimmunity·Urs Christen, Matthias G von Herrath
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Alessandro AntonelliMario Serio
Mar 29, 2005·Diabetes Care·Matilde MasiniPiero Marchetti
Sep 28, 2005·Diabetes Care·Alessandro AntonelliEle Ferrannini
Dec 14, 2005·Current Opinion in Rheumatology·Clodoveo Ferri, Maria Teresa Mascia
Mar 1, 2006·Journal of Diabetes and Its Complications·Hiroshi Noto, Philip Raskin
Mar 11, 2006·Diabetes Care·Marcin SkowrońskiBogna Wierusz-Wysocka
Jul 15, 2006·Thyroid : Official Journal of the American Thyroid Association·Alessandro AntonelliEle Ferrannini
Feb 24, 2007·Rheumatology·D SansonnoF Dammacco
Dec 6, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C FerriA L Zignego
Nov 24, 2007·Autoimmunity Reviews·Clodoveo FerriAnna Linda Zignego

❮ Previous
Next ❯

Citations

Jan 8, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Hiroyuki OshiumiTsukasa Seya
Jul 20, 2012·Rheumatology International·Asli Gamze Sener, Ilhan Afsar
Dec 18, 2008·Clinical Reviews in Allergy & Immunology·Mario García-CarrascoRicard Cervera
Oct 12, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alessandro AntonelliPoupak Fallahi
Apr 23, 2009·Journal of Gastroenterology and Hepatology·Elena VezaliGeorge Saroglou
Jan 1, 2014·World Journal of Gastroenterology : WJG·Vincenza Calvaruso, Antonio Craxì
Feb 18, 2014·Cytokine & Growth Factor Reviews·Alessandro AntonelliPoupak Fallahi
Aug 21, 2013·Cellular & Molecular Immunology·Stephen FaheyAideen Long
Feb 5, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Xiao-Fang LiuHuan Yang
Nov 6, 2013·Autoimmunity Reviews·Alessandro AntonelliPoupak Fallahi
Jan 9, 2010·Journal of Autoimmunity·Pierre YouinouYehuda Shoenfeld
Aug 18, 2009·Journal of Autoimmunity·Aftab A Ansari, M Eric Gershwin
Sep 1, 2009·Autoimmunity Reviews·Siba P RaychaudhuriM Eric Gershwin
Apr 10, 2009·Journal of Autoimmunity·Nancy Agmon-LevinYehuda Shoenfeld
Mar 26, 2009·Autoimmunity Reviews·Loredana SansonnoDomenico Sansonno
Sep 18, 2009·Annals of the New York Academy of Sciences·Merav LidarYehuda Shoenfeld
Mar 23, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Brian B BorgThalachallour Mohanakumar
May 23, 2012·Clinical & Developmental Immunology·Poupak FallahiAlessandro Antonelli
Apr 8, 2010·Advances in Medical Sciences·D A Zarebska-MichalukE Skiba
Jun 21, 2017·International Journal of Molecular Sciences·Isabela SiloşiCristian Adrian Siloşi
Mar 3, 2015·World Journal of Hepatology·Chalermrat BunchorntavakulDisaya Chavalitdhamrong
Dec 17, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Alessandro AntonelliPoupak Fallahi
Jul 25, 2017·Frontiers in Endocrinology·Clodoveo FerriDilia Giuggioli
Nov 16, 2018·Clinical and Experimental Medicine·Franco DammaccoVito Racanelli
Mar 27, 2013·International Journal of Immunopathology and Pharmacology·A AntonelliC Ferri
Apr 20, 2011·Experimental Biology and Medicine·Yee-Shin LinHuan-Yao Lei
May 26, 2016·Reviews in Endocrine & Metabolic Disorders·Poupak FallahiAlessandro Antonelli
Dec 15, 2016·Arthritis Research & Therapy·Anastasiya MuntyanuDafna D Gladman
Dec 1, 2018·Reviews in Endocrine & Metabolic Disorders·Michele ColaciClodoveo Ferri
May 1, 2010·Auto- Immunity Highlights·Barbara C Böckle, Norbert T Sepp
Jan 1, 2016·Terapevticheskiĭ arkhiv·M L ZubkinO N Kotenko
Apr 12, 2014·Hormones : International Journal of Endocrinology and Metabolism·Poupak FallahiAlessandro Antonelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Autoimmune Lymphoproliferative Syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Related Papers

Nature Clinical Practice. Endocrinology & Metabolism
Alessandro AntonelliPoupak Fallahi
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Clodoveo FerriA L Zignego
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Alessandro AntonelliEle Ferrannini
Nature Reviews. Gastroenterology & Hepatology
Alessandro AntonelliPoupak Fallahi
© 2022 Meta ULC. All rights reserved