PMID: 9422330Jan 9, 1998Paper

Immunopathologic responses to Aspergillus antigen in interleukin-4 knockout mice

The Journal of Laboratory and Clinical Medicine
V P KurupJ N Fink

Abstract

Two strains of interleukin-4 (IL-4) gene knockout mice were studied and compared with wild strains to determine the role of IL-4 in the immunopathogenesis of murine allergic aspergillosis. Animals immunized intraperitoneally were subsequently challenged with Aspergillus antigen intranasally. The animals were evaluated for total serum immunoglobulin E (IgE) levels, Aspergillus-specific IgG antibody isotypes, peripheral blood eosinophils, cytokine and chemokine mRNA transcripts in spleen cells, and pulmonary histology. No serum IgE was detected in animals deficient in the IL-4 gene. Aspergillus-specific IgG1 was detected in all animals, while enhanced levels of IgG2a were detected in IL-4 knockout animals challenged with A. fumigatus antigen. There were no differences in the peripheral blood or lung eosinophils in the two groups of mice exposed to A. fumigatus. These results indicate that lung injury in Aspergillus-antigen challenged animals may be the result of the eosinophil mediators and that IgE-mediated injury may not be significant in this model, which may be a significant variation between the model and human allergic aspergillosis.

References

Apr 1, 1977·Annals of Internal Medicine·M RosenbergK E Harris
Jan 10, 1993·The New England Journal of Medicine·E R McFadden, I A Gilbert
Nov 1, 1991·Science·R KühnW Müller
May 1, 1991·The Journal of Allergy and Clinical Immunology·A B Kay
Jan 1, 1990·International Archives of Allergy and Applied Immunology·V P KurupJ N Fink
Oct 11, 1990·The New England Journal of Medicine·J BousquetP Godard
Feb 2, 1989·The New England Journal of Medicine·B BurrowsM G Cline
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
May 1, 1988·The Journal of Allergy and Clinical Immunology·G J GleichP M Vanhoutte
Jan 1, 1988·International Archives of Allergy and Applied Immunology·V P KurupJ N Fink
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·W W BusseL J Rosenwasser
Apr 1, 1995·Thorax·P D Paré, T R Bai
Nov 1, 1994·The Journal of Experimental Medicine·B R RenshawC R Maliszewski
Jun 1, 1994·The Journal of Allergy and Clinical Immunology·V P KurupR L Coffman
Jan 1, 1994·Annual Review of Immunology·B S BochnerL M Lichtenstein
Jan 1, 1994·International Archives of Allergy and Immunology·V P KurupJ N Fink
Jul 1, 1993·The Journal of Allergy and Clinical Immunology·J C Hogg
Jan 28, 1993·The New England Journal of Medicine·S J Galli
Apr 1, 1993·American Journal of Respiratory Cell and Molecular Biology·M B Resnick, P F Weller
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·P D MehlhopH C Oettgen

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Citations

Aug 28, 1998·Research in Immunology·V P KurupP S Murali
Jan 27, 2007·Clinical and Molecular Allergy : CMA·Viswanath P KurupJordan N Fink
Jan 9, 2010·Medical Mycology·Steven P TempletonDetlef Schmechel
Jun 23, 2005·Allergy·I Tillie-Leblond, A-B Tonnel
Mar 10, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V P KurupK J Kelly
Jan 9, 1998·The Journal of Laboratory and Clinical Medicine·R Patterson
Feb 29, 2020·European Journal of Immunology·Axel DietschmannDavid Voehringer
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K BleaseC M Hogaboam
Mar 29, 2001·Medical Mycology·T R Traynor, G B Huffnagle
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K BleaseC M Hogaboam
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M R van ScottS Sur
Mar 17, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V P KurupJ N Fink
Apr 9, 1999·Clinical Microbiology Reviews·J P Latgé

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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