PMID: 9537052Jan 1, 1980Paper

Immunopathologic role of proteoglycan antigens in rheumatoid joint disease

Scandinavian Journal of Immunology
Tibor T GlantT Szücs

Abstract

Cell-mediated immunity to proteoglycan antigens was assessed by leucocyte migration inhibition and by lymphocyte stimulation tests in patients with rheumatoid arthritis or with ankylosing spondylarthritis, in patients with relapsing synovitis after a single trauma to their knee joints, and in healthy donors. Both tests revealed a sensitization in most of the patients examined with various proteoglycan antigens derived from human cartilaginous tissues, rheumatoid synovial fluid, and species-common antigen of bovine nasal cartilage. Antibodies against proteoglycan antigens of human articular cartilage were detected by solid-phase radioimmunoassay in eleven out of twenty-nine sera from patients with rheumatoid arthritis and in four out of six rheumatoid synovial fluids. The results suggest that the cartilage antigenic components released by an inflammatory process or trauma may trigger a vicious circle of chronic inflammation and joint destruction.

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Citations

Apr 15, 1985·Experientia·T Kouri
Jan 1, 1996·Pathology Oncology Research : POR·Edit I BuzásTibor T Glant
Sep 1, 1981·Collagen and Related Research·B R Champion, A R Poole
Jan 1, 1982·Collagen and Related Research·B R ChampionA R Poole
Jan 1, 1985·Collagen and Related Research·G A PringleT R Mosmann
Oct 1, 1996·Immunology·R N BarkerS J Thompson
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J U YooV M Goldberg
Nov 13, 2004·Annals of the Rheumatic Diseases·J ZouJ Sieper
Jan 11, 2005·Annals of the Rheumatic Diseases·T BárdosT T Glant
Aug 1, 1992·Annals of the Rheumatic Diseases·P JobanputraG S Panayi
Sep 1, 1992·Annals of the Rheumatic Diseases·J A Goodacre, J P Pearson
Jan 1, 1995·Scandinavian Journal of Rheumatology. Supplement·T T GlantK Mikecz
Dec 20, 2012·Clinical & Developmental Immunology·Timea BesenyeiZoltan Szekanecz
Oct 1, 1991·Journal of Autoimmunity·J A GoodacreJ Pearson
May 1, 1983·Journal of the American Geriatrics Society·D Hamerman
May 14, 1982·Biochemical and Biophysical Research Communications·T T Glant
Mar 13, 2003·Arthritis and Rheumatism·Guo-Hua YuanKusuki Nishioka
Jul 27, 2006·Arthritis and Rheumatism·Suzanne E BerloTibor T Glant
Feb 1, 1987·Arthritis and Rheumatism·T T GlantA R Poole

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