PMID: 9532006Apr 9, 1998Paper

Immunopathological mechanisms underlying the time-course of Trichinella spiralis cardiomyopathy in rats

Virchows Archiv : an International Journal of Pathology
N PaolocciF Bruschi

Abstract

The present study shows that isolated, perfused hearts from rats orally infected with Trichinella spiralis have a reduced left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow (CF). This reduction is considerably enhanced by a single bolus (100 pM) of PAF (platelet activating factor, an eosinophil activator), especially at 21 days post-infection (d.p.i.), which is the time of the maximum increase in blood and tissue eosinophilia. Helminthic DNA analysis shows that, from 21 d.p.i. onwards, the morphological and functional changes in the myocardium cannot be ascribed to the parasite's presence, whereas its antigens and the attendant immunopathological reactions might have a role in the induction of myocardial damage and dysfunction. Some perivascular inflammatory cells (eosinophils and mast cells) appear to undergo degranulation. All these data suggest a complex sequence of events, from acute myocarditis (21 d.p.i.) which may lead in time (48 d.p.i. onwards) to a dilating cardiomyopathy.

Citations

Mar 29, 2011·Foodborne Pathogens and Disease·Raul NeghinaIosif Marincu
Jan 18, 2002·Postgraduate Medical Journal·F Bruschi, K D Murrell
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Suresh Palaniyandi SelvarajYoshifusa Aizawa
Jul 2, 2011·Biological & Pharmaceutical Bulletin·Sayaka MitoYoshifusa Aizawa
May 15, 2007·Immunological Reviews·Alicia C ReidRoberto Levi
Aug 14, 2015·Nanoscale Research Letters·Fashui HongLei Sheng
Jun 2, 2011·Experimental Parasitology·Dalia S Ashour, Reda H Elbakary
Aug 30, 2008·Trends in Parasitology·Fabrizio BruschiNaohiro Watanabe
Oct 4, 2018·The New England Journal of Medicine·Amarinder SinghBerenice Perez
Nov 19, 2004·European Journal of Immunology·Suresh S PalaniyandiYoshifusa Aizawa
Aug 18, 2020·The American Journal of Medicine·Hirofumi YoshidaMonica K Sikka

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