PMID: 4288700Dec 1, 1966Paper

Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy

The Journal of Experimental Medicine
R C Mellors, C Y Huang

Abstract

A filtrable agent separable from transplantable malignant lymphomas of NZB/Bl mice was capable, upon inoculation into preweanling NZB/Bl mice, of inducing lymphoid cell hyperplasia, hypergammaglobulinemia, proteinuria, hypoalbuminemia, and pathological changes (focal membranous glomerulonephritis) of kidneys-renal functional and structural changes qualitatively similar to those of spontaneous occurrence in older NZB/Bl mice. Viruslike particles with close resemblance to the typical "C" type murine oncogenic virus particles were identified by means of electron microscopy in NZB/Bl mouse tissues and cells, including malignant lymphoma cells, benign lymphoid cells of thymus and spleen, epithelial cells of renal tubules, and extracellular sites. The relevance of these observations, the first of their kind dealing with NZB/Bl mice, is discussed in relation to the several immunopathological disorders which characterize this strain of mice.

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Citations

Oct 1, 1967·Arthritis and Rheumatism·M SiegelN S Peress
Aug 1, 1969·Arthritis and Rheumatism·B H Hahn, L E Shulman
Sep 1, 1970·Arthritis and Rheumatism
May 1, 1973·Arthritis and Rheumatism·R A SylvesterD L Tuffanelli
Jul 1, 1974·Arthritis and Rheumatism·R P Messner
May 1, 1976·Arthritis and Rheumatism·S R BlockC L Christian
Nov 1, 1976·Arthritis and Rheumatism·R E Wolf, M Ziff
May 1, 1970·The American Journal of Medicine·W B Castle
Sep 21, 1968·Nature·D M WeirJ D Naysmith
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Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M J DauphineeA White
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G FernandesR A Good
Jul 1, 1967·The Journal of Experimental Medicine·R C Mellors, C Y Huang
Oct 1, 1967·The Journal of Experimental Medicine·D KofflerH G Kunkel
Mar 1, 1968·The Journal of Experimental Medicine·R J GlassockF J Dixon
May 1, 1969·The Journal of Experimental Medicine·R C MellorsR J Huebner
Jan 1, 1971·The Journal of Experimental Medicine·R C MellorsK Krawczynski
Oct 1, 1973·The Journal of Experimental Medicine·S SugaiN Talal
Sep 15, 1971·Annals of the New York Academy of Sciences·R C Mellors
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May 1, 1974·The Annals of Otology, Rhinology, and Laryngology·N Cauna, D Cauna
Apr 12, 1969·Nature·R D BarnesJ Holliday

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