PMID: 6027647Jul 1, 1967Paper

Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice

The Journal of Experimental Medicine
R C Mellors, C Y Huang

Abstract

Hemolytic disease characterized by slight anemia, reticulocytosis, hemosiderosis, extramedullary hematopoiesis, and positive indirect antiglobulin (Coombs') tests and renal disease with proteinuria, hypoalbuminemia, and glomerular lesions were produced in Swiss mice by neonatal intraperitoneal inoculation of cell-free filtrates prepared from the spleens of old NZB/Bl mice. Lymphoid cell and plasma cell hyperplasia as well as hypergammaglobulinemia occurred in some of these inoculated mice. Type "C" murine oncogenic virus-like particles, indistinguishable from those previously described (1), were shown by electron microscopic study to be present in distinctive locations, notably in the basal foldings of convoluted tubules in the kidneys of a newborn NZB/Bl mouse, old NZB/Bl mice, a CBA x NZB F(1) hybrid mouse, and a Swiss mouse inoculated with NZB/Bl spleen cell-free filtrate. These observations point to two (perhaps related) circumstances which may be requisites for the pathogenic action of this newly discovered virus within and outside the strain NZB: infection of newborn, or infant, mice; persistent, possibly tolerant, infection of adult mice.

References

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Citations

Aug 1, 1969·Arthritis and Rheumatism·B H Hahn, L E Shulman
Sep 1, 1970·Arthritis and Rheumatism
Nov 1, 1973·The Journal of Pathology·M TuffreyR D Barnes
Sep 21, 1968·Nature·D M WeirJ D Naysmith
Apr 17, 1969·The New England Journal of Medicine·J G Sinkovics
Nov 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gabriele B Beck-EngeserMatthias Wabl
Dec 1, 1969·Archives of Environmental Health·R W Leader
Mar 1, 1968·The Journal of Experimental Medicine·P H Lambert, F J Dixon
Jan 1, 1969·The Journal of Experimental Medicine·P J Staples, N Talal
Jan 1, 1971·The Journal of Experimental Medicine·R C MellorsK Krawczynski
Apr 1, 1969·Vox Sanguinis·F Milgrom
Sep 15, 1971·Annals of the New York Academy of Sciences·R C Mellors
Jan 1, 1971·Acta Rheumatologica Scandinavica·O KoivistoT Vesikari
May 1, 1977·Kidney International·P E HoffstenS Klahr
Oct 1, 1975·The American Journal of Medicine·S R Block, C L Christian
Jan 1, 1974·International Journal of Psychiatry in Medicine·W F Kiely
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M Greenwood, A M Greenwood
Jul 15, 1970·International Journal of Cancer. Journal International Du Cancer·A M Denman, E J Denman
Jul 1, 1970·Scottish Medical Journal·K Whaley, W W Buchanan
Dec 1, 1970·CRC Critical Reviews in Clinical Laboratory Sciences·F P Quismorio, G J Friou
Feb 1, 1972·Klinische Wochenschrift·P A Berg
Jan 1, 1974·International Journal of Psychiatry in Medicine·A Amkraut, G F Solomon

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