ImmunoPET in Multiple Myeloma-What? So What? Now What?

Cancers
C BaillyMichel Chérel

Abstract

Despite constant progress over the past three decades, multiple myeloma (MM) is still an incurable disease, and the identification of new biomarkers to better select patients and adapt therapy is more relevant than ever. Recently, the introduction of therapeutic monoclonal antibodies (mAbs) (including direct-targeting mAbs and immune checkpoint inhibitors) appears to have changed the paradigm of MM management, emphasizing the opportunity to cure MM patients through an immunotherapeutic approach. In this context, immuno-positron emission tomography (immunoPET), combining the high sensitivity and resolution of a PET camera with the specificity of a radiolabelled mAb, holds the capability to cement this new treatment paradigm for MM patients. It has the potential to non-invasively monitor the distribution of therapeutic antibodies or directly monitor biomarkers on MM cells, and to allow direct observation of potential changes over time and in response to various therapeutic interventions. Tumor response could, in the future, be anticipated more effectively to provide individualized treatment plans tailored to patients according to their unique imaging signatures. This work explores the important role played by immunotherapeutics i...Continue Reading

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Citations

Feb 6, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Cheng WangWeijun Wei
Dec 1, 2021·Molecular Pharmaceutics·Weijun WeiJianjun Liu

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Methods Mentioned

BETA
biopsy
biopsies
xenografts

Clinical Trials Mentioned

NCT03665155
NCT03311828

Software Mentioned

immunoPET

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