PMID: 7544767Feb 1, 1995Paper

Immunopharmacological activities and clinical development of muramyl peptides with particular emphasis on murabutide

International Journal of Immunopharmacology
G M BahrL Chedid

Abstract

Certain immunopharmacological activities of muramyl peptides have been associated with inflammatory and undesirable side-effects typically observed following the administration of the prototype molecule muramyl dipeptide. This activity is now demonstrated not to be linked to a direct activation of inflammatory processes in endothelial cells. Neither MDP nor other structural derivatives were able to induce inflammatory cytokines release or E-selectin gene expression in cultured human umbilical vein endothelial cells. However, oral administration of muramyl peptides has been reported to induce certain biological effects, including the downregulation of anamnestic, antigen-specific IgE responses, which are not observed following parenteral administration. We elaborate on these findings and extend them to show the efficacy of a new muramyl peptide in suppressing polyclonally induced serum IgE levels in anti-IgD-treated mice. The comparative effects of muramyl peptides, selected for clinical development, on the induction of cytokines in human whole blood are then presented at the level of mRNA accumulation and protein secretion. Moreover, the cytokine profile induced in vitro and in vivo by the combination of the safe immunostimulan...Continue Reading

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Citations

Jun 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F R Vogel
Sep 29, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E C DarcissacG M Bahr
Feb 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G M BahrL A Chedid
Apr 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G M BahrL A Chedid
Nov 15, 1996·European Journal of Biochemistry·G H Werner, P Jollès
Dec 17, 2008·Clinical and Experimental Immunology·N El-JamalK S Echtay
Nov 11, 2010·Bioorganicheskaia khimiia·E A MeshcheriakovaV T Ivanov
Nov 26, 2010·Expert Review of Vaccines·Antu K Dey, Indresh K Srivastava
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathalie ChaputLaurence Zitvogel

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