PMID: 9004185Dec 1, 1996Paper

Immunopharmacological activity of the purified insoluble glucan, zymocel, in mice

The Journal of Pharmacy and Pharmacology
T SuzukiT Yadomae

Abstract

Although it has been established that soluble glucan in fungi is important to host defence against infection, the importance of insoluble glucans is not clear. We have examined the in-vivo immunopharmacological activity of the insoluble glucan, zymocel. Administration of zymocel increased peritoneal exudate cell number and spleen weight, and enhanced: phagocytic activity, hydrogen peroxide production, and nitric oxide production of peritoneal exudate cells; the extravascular release of Evans blue (which might reflect vascular permeability); lipopolysaccharide-triggered synthesis of tumour necrosis factor (TNF); and recovery of white blood cell number in cyclophosphamide-induced leukopenia. Zymocel also showed anti-tumour activity against sarcoma 180 in mice and also enhanced TNF synthesis and hydrogen peroxide production by macrophage-like cell line in-vitro, i.e. resulted in direct macrophage activation. These results show that zymocel shows varied immunopharmacological activity; it is suggested that the administration of insoluble glucan induces the inflammatory response, the subsequent activation of the immune systems via the cytokine network, and direct macrophage activation.

References

May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J K Czop, K F Austen
Apr 14, 1980·Biochemical and Biophysical Research Communications·G A Warr

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Citations

Jul 31, 2001·FEMS Immunology and Medical Microbiology·H TakahashiT Yadomae
Jun 24, 2006·Bioscience, Biotechnology, and Biochemistry·Kyu-Ho HanMichihiro Fukushima
Nov 19, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Margrete BerdalTrond Jenssen
Nov 22, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Margrete BerdalTrond Jenssen
May 7, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Naohito Ohno

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