Immunopharmacology of Chinese medicine 1, ginseng induced immunosuppression in virus-infected mice

The American Journal of Chinese Medicine
H W YeungK N Leung

Abstract

Total saponins extracted from Panax ginseng, when injected into mice at a dose of approximately 10 mg/kg body weight, have no significant effect on the generation of cytotoxic T cell activity, induction of natural killer cell activity and humoral antibody production in mice infected subsequently with A/WSN influenza virus. The saponins, however, selectively suppressed the delayed-type hypersensitivity responses to the virus when administered to the animals before but not after virus sensitization. Thus, ginseng pretreatment can induce immunological unresponsiveness in one arm of the immune system. Such selective immunosuppression effect of the total saponins of ginseng may be related to their steroid-like structure.

Citations

Mar 24, 2004·Integrative Cancer Therapies·Keith I Block, Mark N Mead
Sep 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Alice BalfourierFlorence Gazeau
Jan 1, 1990·Immunopharmacology and Immunotoxicology·J Y KimM I Luster

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