Immunophenotype Heterogeneity in Nasal Glomangiopericytoma

Case Reports in Otolaryngology
Adriana Handra-LucaMarick Lae

Abstract

Nasal glomangiopericytoma is rare. The immunophenotype is heterogeneous, more frequently smooth-muscle-actin and CD34-positive. We report expression patterns for several vascular-related proteins such as CD99, CD146, Bcl2, and WT1 as well as for treatment-related proteins such as mTOR and EGFR in a nasal glomangiopericytoma. The patient (woman, 86 years) presented with a left nasal tumefaction. The resected specimen (1.5-cm) showed a glomangiopericytoma. Tumor cells expressed smooth-muscle-actin, CD31, CD34, and progesterone receptor. They also expressed the vascular-cell-related proteins Bcl2, CD99, CD146, and WT1, as well as mTOR and EGFR. Nasal glomangiopericytomas show immunohistochemical heterogeneity for vascular-related markers, suggesting a possible extensive pericytic differentiation. The expression of potential targets for drug treatments such as mTOR and EGFR may impact on the clinical follow-up of these tumors occurring at advanced ages, which may require complex surgery.

References

Feb 19, 2010·Virchows Archiv : an International Journal of Pathology·Andrea Ambrosini-Spaltro, Vincenzo Eusebi
May 29, 2013·Molecular and Cellular Biochemistry·Zakaria Y Abd ElmageedEmad Kandil
Jun 5, 2013·PloS One·François BertucciDaniel Birnbaum

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Citations

Sep 13, 2018·Head and Neck Pathology·Michihisa KonoHiroshi Nishihara

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Methods Mentioned

BETA
nuclear translocation

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