Immunophenotypic differences between intestinal-type and low-grade papillary sinonasal adenocarcinomas: an immunohistochemical study of 22 cases utilizing CDX2 and MUC2

The American Journal of Surgical Pathology
Helen P Cathro, Stacey E Mills

Abstract

Nonsalivary sinonasal adenocarcinomas can be divided into low-grade and high-grade tumors. The former are often papillary and the latter are usually of intestinal type, morphologically similar to metastatic colonic carcinoma. Antibodies to CDX2, a transcription factor gene highly specific for intestinal adenocarcinomas, MUC2, a mucin gene expressed in adenocarcinomas from various sites, and cytokeratins (CK) 7 and 20 were used to examine the two groups of tumors. Formalin-fixed, paraffin-embedded tissue from 22 sinonasal adenocarcinomas was reclassified into 9 high-grade intestinal-type, 3 high-grade nonintestinal, and 10 low-grade, predominantly papillary adenocarcinomas. Immunohistochemical staining was graded on a 0 to 4+ scale with 5% or greater tumor cell staining considered positive. Of the high-grade intestinal group, 78% demonstrated 4+ CDX2 positivity, with 44% MUC2 positive. Although 89% of this group was CK7 positive, the percent of staining was variable. A majority (67%) of the intestinal cases was 4+ CK20 positive. Almost every nonintestinal adenocarcinoma (90%) (low- and high-grade) was CK7 positive (7 of 9, 4+), without expression of any of the three colonic adenocarcinoma markers. The three high-grade nonintesti...Continue Reading

References

Apr 1, 1991·The American Journal of Surgical Pathology·D W FranquemontS E Mills
Jun 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R A Mickel, M C Zimmerman
Aug 1, 1990·Clinical Otolaryngology and Allied Sciences·A G Maran
Dec 1, 1988·The American Journal of Surgical Pathology·B M WenigD K Heffner
Sep 1, 1988·Archives of Otolaryngology--head & Neck Surgery·D M AlessiT C Calcaterra
Jan 1, 1985·Archives of Oto-rhino-laryngology·K D McClatcheyJ D Schaldenbrand
Mar 1, 1986·The American Journal of Surgical Pathology·L Barnes
Apr 1, 1966·The Laryngoscope·J M BernsteinK Balogh
Dec 1, 1982·The American Journal of Surgical Pathology·S E MillsR W Cantrell
Sep 28, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·P ChuL M Weiss
Oct 24, 2001·The Journal of Pathology·P A SylvesterM G Thomas
Jun 6, 2002·American Journal of Clinical Pathology·Helen P Cathro, Mark H Stoler
Feb 1, 2003·Biochemical and Biophysical Research Communications·Hiroshi YamamotoYasuhito Yuasa
Feb 1, 2003·Journal of Gastroenterology·Akashi EdaKentaro Sugano
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher A MoskalukHenry F Frierson
Sep 26, 2003·The American Journal of Surgical Pathology·Alessandro FranchiMarco Santucci

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Citations

Jul 13, 2013·Head and Neck Pathology·Matthew P TilsonJustin A Bishop
Dec 18, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Samuel A Yousem
Sep 19, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Russell VangBrigitte M Ronnett
Sep 30, 2006·Pathology·C Arnold, V Marjoniemi
Sep 26, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J CrodaM I S Duarte
Sep 28, 2010·Critical Reviews in Oncology/hematology·Alessandro FranchiMarco Santucci
Sep 5, 2006·Human Pathology·Mehsati HerawiJonathan I Epstein
Jan 17, 2017·Human Pathology·Sejal S ShahVishal S Chandan
Feb 6, 2017·Surgical Pathology Clinics·Edward B Stelow
Aug 16, 2008·American Journal of Rhinology·Annarita PalombaAlessandro Franchi
Jun 25, 2010·Advances in Anatomic Pathology·Edward B StelowDiane L Carlson
Feb 8, 2007·Virchows Archiv : an International Journal of Pathology·Abbas AgaimyPeter H Wünsch
Jun 4, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Alena SkalovaMichal Michal
Sep 19, 2009·American Journal of Clinical Pathology·Reda S SaadMahmoud A Khalifa
Aug 12, 2015·International Journal of Surgical Pathology·Jeffrey M BlumbergManju L Prasad
Feb 10, 2006·The Annals of Otology, Rhinology, and Laryngology·Vicente A RestoDerrick T Lin
Aug 27, 2005·Archives of Pathology & Laboratory Medicine·Lindsey B De LottWendy L Frankel
May 18, 2021·Translational Oncology·Jiali GongHongyang Lu
Jan 24, 2007·Annals of Diagnostic Pathology·Jorge Albores-SaavedraRalph Hruban

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