PMID: 9447383Feb 3, 1998Paper

Immunophenotypic heterogeneity of hyalinizing trabecular tumours of the thyroid

Histopathology
Mauro PapottiGianni Bussolati

Abstract

We studied 12 cases of hyalinizing trabecular tumour of the thyroid gland (HTT) with the aim of reviewing the cytological, histological and immunophenotypic features and of investigating the relationships of HTT with other thyroid neoplasms. Eleven patients were female and one male, aged 8-74 years (median 58). Ten cases had a benign behaviour, while two cases were locally aggressive. Of the latter, one developed distant metastases and the other is a recent case. All patients are alive 6-311 months after diagnosis. Cytologically, HTT was characterized by hypercellular smears with aggregates of roundish cells having features of papillary carcinoma (nuclear grooves, vacuoles) and fragments of fibrous tissue. Histologically, prominent nesting, trabecular growth patterns and a hyaline stroma (partly positive for laminin and collagen type IV) were found. One case was associated with a papillary microcarcinoma. Two additional cases had extensive areas of papillary carcinoma. In one of these, hyalinized papillary stalks were observed. All tumours contained thyroglobulin but not calcitonin. High molecular weight cytokeratin (a marker of papillary carcinoma) was focally positive in 4/12 cases only and thyroperoxidase (a marker of follic...Continue Reading

Citations

Oct 26, 2007·Endocrine Pathology·Vânia NoséMauro Papotti
Mar 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Giuliana SalvatoreMassimo Santoro
Aug 24, 2001·International Journal of Pediatric Otorhinolaryngology·P CampisiC Bernard
Dec 16, 2000·The American Journal of Surgical Pathology·M PapottiG Chiappetta
Jun 30, 2004·The American Journal of Surgical Pathology·Mary B CaseyJ Aidan Carney
Jan 5, 2002·Advances in Anatomic Pathology·Ricardo V Lloyd
May 26, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Eugenio LeonardoMauro Papotti
Jul 22, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·José A Ortiz-ReyIosu Antón
Mar 28, 2008·The American Journal of Surgical Pathology·J Aidan Carney
Oct 19, 2004·American Journal of Clinical Pathology·Scott L Boerner, Sylvia L Asa
Aug 30, 2008·Endocrine Journal·Sang-Wook KangCheong Soo Park
Dec 16, 2010·Journal of Cytology·Sumiti GuptaNisha Marwah
Feb 11, 2012·Journal of Endocrinological Investigation·S ArenaF Frasca
Sep 10, 2005·Expert Review of Molecular Diagnostics·Jennifer L Hunt
May 27, 2008·Endocrinology and Metabolism Clinics of North America·Zubair W Baloch, Virginia A LiVolsi
Apr 27, 2013·Histopathology·Daniela LenggenhagerMatthias Rössle
Jul 14, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sarah LeeJa Seung Koo
Feb 24, 2000·The Annals of Otology, Rhinology, and Laryngology·P BoccatoA Ferlito
Oct 2, 2019·Head and Neck Pathology·Esther Diana RossiLiron Pantanowitz
Mar 8, 2008·Journal of Clinical Pathology·G Bussolati, E Leonardo
Jul 6, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Caterina MarchiòMauro Papotti

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