Abstract
Efforts to overcome poor outcomes in patients with adult acute lymphoblastic leukemia (ALL) have focused on combining new therapeutic agents targeting immunophenotypic markers (IPMs) with classical cytotoxic agents; therefore, it is important to evaluate the clinical significance of IPMs. Baseline characteristics and clinical outcomes of patients with adult ALL were retrospectively analyzed. The percentage of blasts expressing IPMs at diagnosis was measured by multicolor flow cytometry analysis. Samples in which ≥20% of blasts expressed an IPM were considered positive. Among the total patient population (N=230), almost all (92%) were in first or second hematological complete remission (HCR) and 54% received allogeneic hematopoietic cell transplant (allo-HCT). Five-year hematologic relapse-free survival (HRFS) and overall survival (OS) rates were 36% and 39%, respectively, and 45.6% and 80.5% of patients were positive for the IPMs CD20 and terminal deoxynucleotidyl transferase (TdT), respectively. Expression of CD20, CD13, CD34, and TdT was associated with HRFS rate, and expression of CD20 and CD13 was associated with OS rate, as was the performance of allo-HCT. In multivariate analysis, positivity for CD20 (HRFS: hazard ratio [...Continue Reading
References
Mar 1, 1988·European Journal of Haematology·E R van WeringB E van der Linden-Schrever
Jan 1, 1987·Leukemia Research·M L HetheringtonG R Buchanan
Aug 10, 2006·Blood·Sima JehaChing-Hon Pui
Sep 7, 2006·Cancer·Helene HallböökUNKNOWN Swedish Childhood Leukemia Group
Dec 1, 2007·Blood·Anthony H GoldstoneJacob M Rowe
Aug 16, 2008·Blood·Deborah A ThomasHagop M Kantarjian
May 15, 2009·Leukemia·B-S ChoC-C Kim
Sep 24, 2009·Haematologica·Sébastien MauryUNKNOWN Group for Research on Adult Acute Lymphoblastic Leukemia
Nov 21, 2009·American Journal of Clinical Pathology·Adam C SeegmillerRobert W McKenna
May 15, 2010·Blood·Farhad RavandiHagop Kantarjian
Jul 28, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deborah A ThomasHagop M Kantarjian
Aug 19, 2010·Blood·Mohamad MohtyUNKNOWN Acute Leukemia Working Party of EBMT
Mar 16, 2011·Blood·Veronika BachanovaDaniel Weisdorf
Apr 12, 2012·Blood·Nicola GökbugetUNKNOWN German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia
Apr 6, 2013·Annals of Hematology·Sang Min LeeUNKNOWN Korean Society of Hematology Adult ALL working party
Apr 27, 2013·American Journal of Hematology·Ki-Seong EomSeok Lee
Nov 28, 2013·Blood·Adele K FieldingAnthony H Goldstone
Nov 20, 2014·American Journal of Hematology·Elias JabbourHagop Kantarjian
Dec 20, 2014·The Lancet Oncology·Max S ToppHagop M Kantarjian
Jun 13, 2015·Blood·Dae-Young KimUNKNOWN Adult Acute Lymphoblastic Leukemia Working Party of the Korean Society of Hematology
Aug 1, 2015·American Journal of Hematology·Sung-Nam LimDae-Young Jang
Oct 21, 2015·Blood·Gerhard ZugmaierMax S Topp
Citations
Nov 25, 2016·Leukemia·C RodmanC D Porada
Jul 20, 2017·International Journal of Laboratory Hematology·S D JalalA A S Al Doski
Oct 3, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Kwun Wah Wen, Ryan M Gill
Jan 6, 2021·Nucleic Acids Research·Jon AshleyYi Sun
Apr 20, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Dyna Jaza MohammedNasir Abdulsalam Al-Allawi