Immunophenotypic shift of memory CD8 T cells identifies the changes of immune status in the patients after liver transplantation.

Scandinavian Journal of Clinical and Laboratory Investigation
Yuling SunShusen Zheng

Abstract

Chronic or acute rejection is a leading cause of allograft loss after solid organ transplantation and the presence of memory T cells is associated with increased propensity for allograft rejection. The purpose of this study was to investigate the correlation between immunophenotypic shift of memory CD8+ T cells and immune status in the patients after liver transplantation. Seventy-three blood samples were collected and varied compartments of memory CD8+ T cells were analysed in non-rejected and rejected patients. The results show that with time elapsed, the immunophenotypes of memory CD8+ cells shifted from naive T cells to central or intermediate memory cells, and then to effector or terminal memory cells in non-rejected patients. This course was correlated with the expression of CD127 on CD8+ T cells. In rejected patients, the main proportion of CD8+ cells were dominated by naive CD8+ cells and then rapidly restored to the immunophenotypes of memory T cells after effective treatment. These results demonstrated that immunophenotypic shift of memory CD8+ T cells was closely related to the change of the immune status in the patients after liver transplantation. Monitoring the immunophenotypic shift of memory CD8+ T cells is of g...Continue Reading

References

Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Nov 14, 1997·The Journal of Experimental Medicine·D HamannR A van Lier
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
Mar 10, 2001·Nature·P ChampagneG Pantaleo
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroko TomiyamaMasafumi Takiguchi
Dec 5, 2002·Trends in Immunology·Debbie van BaarleFrank Miedema
Feb 4, 2003·Nature Immunology·E John WherryRafi Ahmed
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katharina M HusterDirk H Busch
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Adam W Bingaman, Donna L Farber
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mirko PaiardiniGuido Silvestri
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen L ShiaoJordan S Pober
Feb 1, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shusen ZhengMin Zhang
Jul 11, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christian StremmelAnthony Slavin

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Citations

Sep 25, 2021·Circulation. Heart Failure·William Bracamonte-BaranDaniela Čiháková
Sep 29, 2021·Current Opinion in Organ Transplantation·Mateo Cuervo FlorezAli Zarrinpar

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