Immunophenotyping of lymphocyte subsets in the third eyelid tissue in dogs (Canis familiaris): morphological, microvascular, and secretory aspects of this ocular adnexa

Microscopy Research and Technique
G Alexandre-PiresJ A Esperança Pina

Abstract

The third eyelid is an important adnexa of the eye. The objective of this study was to evaluate (i) morphological aspects (ii) vascularization, and (iii) the immunophenotype of lymphocyte subsets in the third eyelid of dogs. Flow cytometric analysis revealed the presence of three patterns concerning the immunophenotype of the third eyelid tissue. Dogs without ocular insult or deficient tear production might belong to one of the following immunophenotype patterns: I--the number of T-cells that expressed CD3(+) CD8(+) was higher than the number of cells that expressed CD3(+)CD4(+). II--the number of cells CD3(+)C4(+) was higher than the number of cells CD3(+)CD8(+) and in this case a higher number of cells that expressed CD19 were identified. III--Proximity of values of the cells that expressed CD3(+)CD4(+) and CD3(+)CD8(+). These data might suggest that the number of lymphocyte T cells alone should not be considered a direct indicator of the presence of an immune-based inflammation. Besides, a particular population of T-cells does not indicate a particular inflammatory state. The morphological study of the third eyelid revealed a rather uncommon angioarchitecture. The artery that irrigates the eyelid crosses almost the entire le...Continue Reading

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Apr 6, 2006·Microscopy Research and Technique·G Alexandre-PiresJ A Esperança Pina
Jul 11, 2006·Immunological Reviews·Christopher A KlebanoffNicholas P Restifo

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Citations

Sep 2, 2010·Experimental Eye Research·Yasuyoshi UmedaAkira Murakami
Jan 5, 2011·Veterinary Ophthalmology·Il-Hwa HongKyu-Shik Jeong

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