Immunophenotyping of skin cells during healing of suction blister injury

M K ReuschV B Morhenn


The time course of appearance and the dynamic changes of immunocompetent cells were assessed in human skin following sterile suction blister would healing. During epidermal regeneration, a local increase in Langerhans cells (LC) and the appearance of a mononuclear cell infiltrate were observed. Initially, T cells were exclusively of the T helper/inducer subtype, whereas during the later stages of the healing process an increasing number of cytotoxic/suppressor T cells (up to 30%) was observed. Keratinocytes of neither the adjacent nor the newly formed epidermis expressed HLA-DR over the course of the wound-healing process. Our results suggest that immune-competent cells such as T cells and LC may play an important role in the regulation of the wound-healing process.


Apr 1, 1988·Immunology Today·V B Morhenn
Mar 1, 1996·Molecular Medicine Today·G E Sale
Jan 14, 2000·Journal of Anatomy·A D Agaiby, M Dyson
Apr 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K RosnerG L Vejlsgaard
Apr 12, 2012·Clinical Microbiology Reviews·Margaret A Stanley
Jun 27, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Irena Hočevar-BoltežarMiha Zargi
Feb 11, 2016·Advances in Wound Care·Amanda S MacLeod, Jonathan N Mansbridge
Jan 10, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Heidi F LarsenMagnus S Ågren

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