Immunopontentiating and antitumor activities of the purified polysaccharides from Phellodendron chinese SCHNEID

Life Sciences
Sun-Dong ParkCheorl-Ho Kim

Abstract

The polysaccharide fractions were isolated and purified from Phellodendron chinese SCHNEID, and antitumor activities were examined at dosages of 2, 5 and 10 mg/100 g. F-7 and F-8 showed the highest tumor inhibitory activities (inhibition ratio 96.4 and 98.2% in 2 mg/100 g), and in dose of 5 mg/100 g, the inhibitory ratios were 95.3 and 97.5%, respectively. Furthermore, 10 mg/100 g of intraperitoneal (i.p.) injection gave 97.3 and 98.7% of inhibition. In oral administration, the inhibitory activities were not markedly observed, indicating that the polysaccharides are directly acting to immune system. Also the polysaccharides increased the number of circulating blood leukocytes and total peritoneal exudate cells. Although implantation of tumor cells greatly decreased the productivity of antibody (antibody-mediated) and T lymphocyte reactivity (delayed-type) as 6.3 from 9.3 and 5.9 from 7.7, represented by the increase of footpad thickness, respectively. The polysaccharides elevated the reactivity of T lymphocyte in tumor-bearing mice, which were rapidly recovered by discontinuance of sample treatments. Especially, F-2, F-5, F-7 and F-8 remarkably recovered the decreased sensitivity. When the effects on thymidylate synthase (TS) a...Continue Reading

References

Dec 1, 1975·Journal of Biochemistry·H Nawata, T Kamiya
Dec 23, 1977·Biochimica Et Biophysica Acta·P V Danenberg
Aug 21, 1978·Life Sciences·G WeberE Olah
Jun 15, 1976·Molecular and Cellular Biochemistry·S Kit
Jul 1, 1991·European Journal of Immunology·L Di RenzoE Klein
Aug 25, 1972·Biochimica Et Biophysica Acta·M A Stafford, O W Jones
Jan 5, 1971·Biochemistry·R B DunlapF M Huennekens
Jan 1, 1981·Journal of Immunological Methods·R G Titus, J M Chiller
May 25, 1984·Journal of Immunological Methods·G M HenningsenC A Osborne
Dec 1, 1980·Pediatric Research·A HerzfeldI Gore
Dec 1, 1994·Bioscience, Biotechnology, and Biochemistry·N Kataoka-ShirasugiA Misaki
May 1, 1996·International Journal of Immunopharmacology·H M KimI D Yoo
Dec 25, 2002·Biological & Pharmaceutical Bulletin·Noriko KodamaHiroaki Nanba
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Toshie HaradaNaohito Ohno
Jan 7, 2004·Journal of Agricultural and Food Chemistry·Tina T X DongKarl W K Tsim
Jan 17, 2004·Biochimica Et Biophysica Acta·Sondra H BergerLukasz Lebioda
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yue-Yawn Chen, Hung-Min Chang
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·M N FornierG K Schwartz

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Citations

Jun 15, 2005·International Immunopharmacology·Guohua ZhaoZongdao Chen
Jun 3, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu Jin KimSoo-Jin Jeong
Nov 28, 2006·Phytotherapy Research : PTR·Seok-Jong SuhCheorl-Ho Kim
May 7, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yue SunAngela Wei Hong Yang
May 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peng-Fei WangFeng Qiu

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