PMID: 7536225Jan 3, 1995Paper

Immunopositive GABAergic neural sites display nitric oxide synthase-related NADPH diaphorase activity in the human colon

Journal of the Autonomic Nervous System
K NicholsA Krantis

Abstract

In the enteric nervous system, gamma-aminobutyric acid (GABA) is a transmitter of interneurons which are proposed to innervate excitatory and inhibitory motor neurons. Nitric oxide (NO) is a putative transmitter of enteric inhibitory motor nerves targeted by GABA. In addition, NO is synthesized by a variety of enteric nerves throughout the gut wall indicative of its potential to be a transmitter of other nerve types, including interneurons. We sought to determine if some populations of nitrergic neurons are interneurons in human infant colon. As enteric neural GABA is exclusive to interneurons, colocalization with NO synthase-related NADPH diaphorase was examined. GABA-transaminase (GABA-T) immunohistochemistry was used to identify GABAergic neurons and a histochemical protocol was used as a marker of neuronal NO synthase-related NADPH diaphorase activity in enteric layers. GABA-T immunoreactive neurons were seen in the ganglionated nerve networks of the myenteric and submucosal layers. GABA-T immunoreactive fibres were also present in the longitudinal and circular muscle layers. A subpopulation of GABA-T immunoreactive neurons within both the myenteric and submucosal ganglia express NO synthase-related activity. This colocaliz...Continue Reading

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Citations

Nov 17, 2009·Histochemistry and Cell Biology·Axel BrehmerWinfried Neuhuber
Sep 24, 1999·Journal of the Autonomic Nervous System·M E DonatA Krantis
Mar 20, 1998·Comparative Biochemistry and Physiology. Part A, Physiology·R Schleiffer, F Raul
Jul 11, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Geboes, S Collins
Jun 7, 2008·Digestive Diseases and Sciences·Edibe KarasuArda Tasatargil
Nov 4, 2010·Glia·Moonhee LeePatrick L McGeer
Aug 20, 2005·Pharmacological Reviews·Noboru Toda, Arnold G Herman
May 12, 2019·The Journal of Physiology·Emanuel Loeza-AlcocerMichael S Gold
Nov 14, 1998·The American Journal of Physiology·I GlasgowA Krantis
Nov 14, 1998·The American Journal of Physiology·A KrantisI Glasgow

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