PMID: 6407746Jul 15, 1983Paper

Immunoproliferative small intestinal disease in Algerians. I. Light microscopic and immunochemical studies

Cancer
F AsselahH Asselah

Abstract

Twenty-two cases of immunoproliferative small intestinal disease (IPSID) were studied with an immunoperoxidase technique. Sixteen of these had serologic evidence of alpha heavy chain disease (AHCD) and have a characteristic immunochemical pattern that allows a diagnosis on jejunal biopsy. kappa-light chain was found in a case of AHCD in the benign appearing plasma cell proliferation and in the associated malignant lymphoma suggesting that failure of light chains is not constant in AHCD. Four cases of IPSID showed secretion of polyclonal IgA in the plasma cell infiltrate providing evidence that some cases may be associated with secretion of complete IgA molecules. This polyclonal pattern is suggestive of a reactive process. Two cases of IPSID without evidence of AHCD showed an immunohistochemical pattern characteristic of AHCD and may represent nonsecreting forms of the disease. Alternatively they may be secreting nondetectable amounts of AHCD protein or an abnormal protein not recognized by standard antisera.

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Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·G Kelényi
Nov 2, 2005·The Cancer Journal·Philip A Salem, Fadi F Estephan
Jun 1, 1985·Journal of Clinical Pathology·P G Isaacson, S K Price
Nov 1, 1987·Journal of Clinical Pathology·W J SmithP G Isaacson
May 1, 1989·European Journal of Cancer & Clinical Oncology·N S el SaghirA E Stuart
Jan 1, 1988·Critical Reviews in Oncology/hematology·R A Kyle, P A Greipp
Jan 1, 1994·The British Journal of Surgery·I G Martin, M I Aldoori
Feb 1, 1987·Cancer·L Y ShihT T Kuo
Aug 9, 2006·European Journal of Gastroenterology & Hepatology·Ioanna EconomidouTheodora Papadakis
Jun 1, 1991·Scottish Medical Journal·C KyriacouR E Mass

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