PMID: 7086976May 1, 1982Paper

Immunoprophylaxis of a murine bladder cancer with high dose BCG immunizations

The Journal of Urology
A S Pang, A Morales

Abstract

The immunoprophylactic effect of Mycobacterium bovis, strain Bacillus Calmette-Guerin (BCG) was studied in a syngeneic bladder tumor system. Injection of a high dose of viable BCG 10 days before tumor cell challenge induced a 46 per cent reduction in tumor take. On the other hand, no protection against tumor take was afforded by the simultaneous administration of BCG and tumor cells. Complete tumor regression, however, was observed in a number of animals of the 2 groups receiving BCG: 90 per cent in the group receiving the vaccine and the tumor simultaneously and 50 per cent in those being immunized 10 days before tumor challenge. These findings indicate that high dose, viable BCG immunization favorably alters the course of this experimental tumor.

References

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Citations

Jun 1, 1984·The Journal of Urology·A Morales, A S Pang
Dec 1, 1991·DICP : the Annals of Pharmacotherapy·J T Moss, D Kadmon
Jan 1, 1986·Urological Research·R A Gardiner

Related Concepts

BCG Vaccine
Malignant Neoplasm of Urinary Bladder
Variolation
Natural Killer Cells
Mice, Inbred C3H
Neoplasms, Experimental

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