PMID: 7086976May 1, 1982Paper

Immunoprophylaxis of a murine bladder cancer with high dose BCG immunizations

The Journal of Urology
A S Pang, A Morales


The immunoprophylactic effect of Mycobacterium bovis, strain Bacillus Calmette-Guerin (BCG) was studied in a syngeneic bladder tumor system. Injection of a high dose of viable BCG 10 days before tumor cell challenge induced a 46 per cent reduction in tumor take. On the other hand, no protection against tumor take was afforded by the simultaneous administration of BCG and tumor cells. Complete tumor regression, however, was observed in a number of animals of the 2 groups receiving BCG: 90 per cent in the group receiving the vaccine and the tumor simultaneously and 50 per cent in those being immunized 10 days before tumor challenge. These findings indicate that high dose, viable BCG immunization favorably alters the course of this experimental tumor.


Aug 12, 1976·Nature·S A WolfeC S Henney
Jan 1, 1976·Annals of the New York Academy of Sciences·M J MastrangeloR E Bellet
Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·H F Pross, M G Baines
Jan 1, 1976·Annals of the New York Academy of Sciences·R W BaldwinM V Pimm
May 1, 1976·The Medical Clinics of North America·F C Sparks
Jun 20, 1974·The New England Journal of Medicine·R C BastH J Rapp
Oct 1, 1974·Cancer·B Zbar, H J Rapp
Jul 15, 1974·International Journal of Cancer. Journal International Du Cancer·D O Chee, A J Bodurtha
Oct 18, 1973·The New England Journal of Medicine·F C SparksD L Morton
Jan 1, 1981·Journal of Immunological Methods·P C OttenhofM G Baines


Jun 1, 1984·The Journal of Urology·A Morales, A S Pang
Dec 1, 1991·DICP : the Annals of Pharmacotherapy·J T Moss, D Kadmon
Jan 1, 1986·Urological Research·R A Gardiner

Related Concepts

BCG Vaccine
Malignant Neoplasm of Urinary Bladder
Natural Killer Cells
Mice, Inbred C3H
Neoplasms, Experimental

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.