Immunoprophylaxis with a monoclonal anti-IL-2 receptor antibody in liver transplant patients

Transplantation
B NashanR Pichlmayr

Abstract

The immunosuppressive effect of a monoclonal antibody (moAb), BT563, directed to the alpha-chain of the IL-2R (CD25), was analyzed in a prospective nonrandomized trial and a prospective randomized trial. Primary objectives were evaluation of the incidence of acute rejections and infections; secondary objectives were safety and tolerability of the moAb. A total of 28 patients were enrolled (phase II) to receive 10 mg/day of BT563 (12 days) as immunoprophylaxis in combination with cyclosporine, azathioprine, and low-dose steroids. Subsequently 32 patients were randomly assigned (phase III) to receive BT563 (10 mg/day) for 12 days or ATG (5 mg/kg/day) for 7 days in addition to cyclosporine and low-dose steroids. No side effects of the BT563 treatment were noted. The actuarial survival was 82% at 12 months in the phase II trial and 92% at 12 months in both arms of the phase III trial. There was one acute rejection in the phase II trial. No acute rejections were noted in the BT arm of the phase III trial and 5 acute rejections were treated in the ATG arm. In the phase II trial 7 infectious episodes were observed, while one infection was seen in the BT arm and 7 in the ATG arm of the triple immunosuppression phase III trial. In all p...Continue Reading

References

Jun 1, 1991·Immunology Today·A N AkbarG Janossy
Apr 1, 1991·Transplantation·H J SchlittR Pichlmayr
May 16, 1991·The New England Journal of Medicine
Aug 8, 1985·The New England Journal of Medicine·UNKNOWN Ortho Multicenter Transplant Study Group
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J W Kupiec-WeglinskiT B Strom
Dec 1, 1981·The Journal of the New York State Nurses' Association·E E Beletx
Dec 1, 1984·Transplantation·J R ThistlethwaiteP S Russell
Nov 1, 1982·European Journal of Immunology·L ChatenoudJ F Bach
Mar 1, 1993·Transplantation·B DoussetJ M Neuberger

❮ Previous
Next ❯

Citations

Dec 26, 2001·Transplantation Proceedings·R GanschowM Burdelski
Feb 1, 1997·Cellular Signalling·R Resta, L F Thompson
Jul 4, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Andrew B AdamsKenneth A Newell
Feb 1, 1997·Alimentary Pharmacology & Therapeutics·S A Mitchell, R W Chapman
Dec 21, 2002·International Journal of Dermatology·Don MehrabiCalvin O McCall
Mar 13, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S EmreC M Miller
Feb 28, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Peter NeuhausUNKNOWN CHIC 304 International Liver Study Group
Jul 19, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gerit NiemeyerBjoern Nashan
Nov 5, 2005·Pediatric Transplantation·Rainer GanschowMartin Burdelski
Jul 28, 2010·Alimentary Pharmacology & Therapeutics·S K AsraniP G Dean
Dec 3, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Florian Wolfgang Rudolf VondranReinhard Schwinzer
Jun 6, 2014·The Cochrane Database of Systematic Reviews·Luit PenningaChristian Gluud
Apr 1, 2017·The Cochrane Database of Systematic Reviews·Manuel Rodríguez-PerálvarezKurinchi Selvan Gurusamy
Jun 1, 2014·The Cochrane Database of Systematic Reviews·Luit PenningaChristian Gluud
Sep 20, 2007·The Journal of Medical Investigation : JMI·Shinji KawahitoYukihiko Nosé
Sep 19, 2001·Pediatric Transplantation·R GanschowM Burdelski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.