PMID: 9419215Jan 31, 1998Paper

Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits

The Journal of Experimental Medicine
Thomas A GriffinRobert A Colbert

Abstract

LMP2, LMP7, and MECL are interferon gamma-inducible catalytic subunits of vertebrate 20S proteasomes, which can replace constitutive catalytic subunits (delta, X, and Z, respectively) during proteasome biogenesis. We demonstrate that MECL requires LMP2 for efficient incorporation into preproteasomes, and preproteasomes containing LMP2 and MECL require LMP7 for efficient maturation. The latter effect depends on the presequence of LMP7, but not on LMP7 catalytic activity. This cooperative mechanism favors the assembly of homogeneous "immunoproteasomes" containing all three inducible subunits, suggesting that these subunits act in concert to enhance proteasomal generation of major histocompatibility complex class I-binding peptides.

References

Jan 1, 1985·Immunogenetics·R D SalterP Cresswell
Nov 17, 1995·The Journal of Biological Chemistry·Y YangP A Peterson
Apr 28, 1995·Science·E SeemüllerW Baumeister
Jan 1, 1995·The Biochemical Journal·K B HendilW Uerkvitz
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·M GaczynskaA L Goldberg
Aug 26, 1994·Science·H J FehlingH von Boehmer
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·S D PatelH O McDevitt
Apr 1, 1996·European Journal of Immunology·M GroettrupP M Kloetzel
Apr 1, 1996·The Journal of Experimental Medicine·H HisamatsuK Tanaka
Aug 1, 1996·Nature·E SeemullerW Baumeister
Jan 1, 1996·Annual Review of Biochemistry·O CouxA L Goldberg
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·M GroettrupP M Kloetzel

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Citations

Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·T FrisanM G Masucci
Apr 6, 2006·Journal of Biosciences·Dipankar NandiDilip Chandu
Mar 23, 2006·Immunogenetics·Larry J DishawCharles H Bigger
Mar 11, 2009·International Journal of Colorectal Disease·Alexander VisekrunaUlrich Steinhoff
Mar 12, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sankar Surendran, Srinivasagam Rajasankar
Dec 10, 2013·Bulletin of Experimental Biology and Medicine·E E ShashovaE L Choinzonov
Jan 22, 2004·Biochemical and Biophysical Research Communications·Krupakar Jayarapu, Thomas A Griffin
Sep 11, 2002·Archives of Biochemistry and Biophysics·Shaneen SinghB J Wagner
Aug 30, 2002·Molecular Immunology·Alice SijtsPeter-M Kloetzel
Feb 11, 2003·Journal of Neuroimmunology·Marco PiccininiMaria Teresa Rinaudo
Feb 27, 1999·Current Opinion in Immunology·K Früh, Y Yang
Feb 27, 1999·Current Opinion in Immunology·P M van Endert
Apr 8, 2000·Current Opinion in Structural Biology·P ZwicklA Steven
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·Shigeo MurataKeiji Tanaka
May 8, 2010·Organic & Biomolecular Chemistry·Martijn VerdoesHerman S Overkleeft
Jan 10, 2003·Journal of Gastroenterology and Hepatology·Takuya MiyagiNorio Hayashi
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Benoît GuillaumeBenoît J Van den Eynde
Oct 5, 2011·Molecular & Cellular Proteomics : MCP·Noel García-MedelJosé A López de Castro
Jul 27, 2001·Diabetes Technology & Therapeutics·T Hayashi, D Faustman
Sep 15, 2007·Antioxidants & Redox Signaling·Katja KotschHans-Dieter Volk
Jul 16, 2013·Journal of the National Cancer Institute·Patrizia LeoneVito Racanelli
Aug 30, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zheqing P CaiLewis C Becker
Sep 23, 2010·Transplantation·Katja KotschJohann Pratschke
Oct 3, 2006·Biochemistry. Biokhimii︠a︡·N P SharovaP A Erokhov
May 7, 2008·Biochemistry. Biokhimii︠a︡·V I MelnikovaL A Zakharova
Mar 10, 2010·Biochemistry. Biokhimii︠a︡·A V SorokinL P Ovchinnikov

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