PMID: 15356141Sep 10, 2004Paper

Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus

The Journal of Immunology : Official Journal of the American Association of Immunologists
Michael BaslerMarcus Groettrup

Abstract

The cytotoxic T cell response to pathogens is usually directed against a few immunodominant epitopes, while other potential epitopes are either subdominant or not used at all. In C57BL/6 mice, the acute cytotoxic T cell response against lymphocytic choriomeningitis virus is directed against immunodominant epitopes derived from the glycoprotein (gp33-41) and the nucleoprotein (NP396-404), while the gp276-286 epitope remains subdominant. Despite extensive investigations, the reason for this hierarchy between epitopes is not clear. In this study, we show that the treatment of cells with IFN-gamma enhanced the presentation of gp33-41, whereas presentation of the gp276-286 epitope from the same glycoprotein was markedly reduced. Because proteasomes are crucially involved in epitope generation and because IFN-gamma treatment in vitro and lymphocytic choriomeningitis virus infection in vivo lead to a gradual replacement of constitutive proteasomes by immunoproteasomes, we investigated the role of proteasome composition on epitope hierarchy. Overexpression of the active site subunits of immunoproteasomes LMP2, LMP7, and MECL-1 as well as overexpression of LMP2 alone suppressed the presentation of the gp276-286 epitope. The ability to g...Continue Reading

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Citations

Nov 3, 2006·Journal of Virology·Michael D RobekFrancis V Chisari
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael BaslerJohn J Monaco
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Britta StrehlUlrich Steinhoff
Mar 16, 2007·European Journal of Immunology·Michael Basler, Marcus Groettrup
Apr 22, 2008·The Journal of Biological Chemistry·Britta StrehlUlrike Kuckelkorn
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Petra RiedlReinhold Schirmbeck
Jun 8, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael BaslerChristopher J Kirk
Sep 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Khalid W KalimMarcus Groettrup
Dec 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabio LucianiWeisan Chen
Jan 24, 2014·Pathogens and Disease·Chrysanthi ParanavitanaMikeljon Nikolich
Nov 18, 2014·European Journal of Immunology·Damien Zanker, Weisan Chen
Apr 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Caroline A BernhardThomas Brocker
Sep 25, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefanie BuergerMichael Basler
May 12, 2016·Minerva pediatrica·Massimiliano BergalloPaolo Tavormina
Sep 17, 2018·Immunogenetics·Michael BaslerMarcus Groettrup
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Aug 29, 2006·PLoS Computational Biology·Almut SchererSebastian Bonhoeffer
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael BaslerMarcus Groettrup
Dec 27, 2011·Nature Immunology·Eleanor Z KincaidKenneth L Rock
Oct 16, 2015·European Journal of Immunology·Sarah MundtMichael Basler
Jan 9, 2014·EMBO Molecular Medicine·Michael BaslerChristopher J Kirk
Dec 6, 2014·Chembiochem : a European Journal of Chemical Biology·Kimberly Cornish CarmonyKyung-Bo Kim
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacques ChapiroBenoît J Van den Eynde
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Nov 26, 2010·European Journal of Immunology·Jacqueline MoebiusMichael Basler
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Oct 17, 2017·British Journal of Pharmacology·Michael BaslerMarcus Groettrup
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Dec 17, 2009·Nature Reviews. Immunology·Marcus GroettrupMichael Basler
Oct 27, 2017·European Journal of Immunology·Michael BaslerMarcus Groettrup
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