Immunoprotective Effect of Probiotic Dahi Containing Lactobacillus acidophilus and Bifidobacterium bifidum on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice

Probiotics and Antimicrobial Proteins
Sagar R JadhavVinod K Kansal

Abstract

In the present study, probiotic Dahi (LaBb Dahi) containing Lactobacillus acidophilus LaVK2 and Bifidobacterium bifidum BbVK3 was selected as a probiotic therapy to investigate its protective effect on dextran sodium sulfate (DSS)-induced ulcerative colitis model in mice that mimics the picture in human. LaBb Dahi was prepared by co-culturing Dahi bacteria (Lactococcus lactis ssp. cremoris NCDC-86 and Lactococcus lactis ssp. lactis biovar diacetylactis NCDC-60) along with selected strain of L. acidophilus LaVK2 and B. bifidum BbVK3 in buffalo milk (3% fat). Four groups of swiss albino male mice (12 each) were fed buffalo milk (3% fat), buffalo milk (3% fat) plus DSS, Dahi plus DSS, and LaBb Dahi plus DSS, respectively, for 17 days with basal diet. The myeloperoxidase (MPO) activity, levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interferon (IFN-γ) were assessed as inflammatory markers, and the histopathological picture of the colon of mice was studied. DSS-induced colitis appeared to induce significant increase in MPO activity, levels of TNF-α, IL-6 and IFN-γ. Feeding with LaBb Dahi offered significant reduction in MPO activity, levels of TNF-α, IL-6 and IFN-γ when compared to either buffalo milk group or g...Continue Reading

References

Nov 1, 1992·Gastroenterology·E LangholzV Binder
Mar 1, 1982·The Journal of Investigative Dermatology·P P BradleyG Rothstein
Mar 1, 1994·Baillière's Clinical Gastroenterology·T T MacDonald, S H Murch
Apr 30, 1999·Gastroenterology·K L MadsenR N Fedorak
May 8, 1999·The American Journal of Clinical Nutrition·M D Collins, G R Gibson
Apr 25, 2000·Annual Review of Medicine·K A Papadakis, S R Targan
Nov 28, 2002·Inflammatory Bowel Diseases·Oren ShiboletDaniel Rachmilewitz
Aug 5, 2004·Inflammatory Bowel Diseases·Richard N Fedorak, Karen L Madsen
Sep 9, 2004·Alimentary Pharmacology & Therapeutics·W Kruis
Jun 30, 2005·The American Journal of Gastroenterology·Rodrigo BibiloniR Balfour Sartor
Aug 9, 2005·International Journal of Food Microbiology·M V HeríasJ E van Dijk
Aug 13, 2005·World Journal of Gastroenterology : WJG·Ping ZhengLun-Gen Lu
Apr 25, 2006·Journal of Clinical Gastroenterology·Kevin P Rioux, Richard N Fedorak
Jun 7, 2006·Postgraduate Medical Journal·A-P Bai, Q Ouyang
Jul 11, 2006·Journal of Clinical Gastroenterology·Miguel RegueiroScott Plevy
Apr 19, 2007·Alimentary Pharmacology & Therapeutics·S L JakobovitsS P L Travis
Jun 15, 2007·Digestive Diseases and Sciences·Aiping BaiXianmin Fan
Sep 21, 2007·Cancer Biology & Therapy·Joanne M BowenDorothy M K Keefe
Feb 5, 2008·Gastroenterology·R Balfour Sartor
May 23, 2008·The American Journal of Gastroenterology·James D LewisBrian L Strom
Sep 2, 2010·World Journal of Gastroenterology : WJG·Sahar K Hegazy, Mohamed M El-Bedewy

❮ Previous
Next ❯

Citations

Aug 12, 2018·Nutrients·Lourdes Santiago-LópezAarón F González-Córdova
Jan 25, 2018·Journal of Agricultural and Food Chemistry·So Young OhGeun Eog Ji

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.