Immunoquantitation of some cytochrome P-450 isozymes in liver microsomes from streptozotocin-diabetic rats

Experientia
E RouerJ P Leroux

Abstract

Streptozotocin-diabetes in rats leads to a decrease of cytochrome P-450 UT-A (the major form in control rats) and an increase of cytochrome P-450 PB-B (the major one induced by phenobarbital treatment) in liver microsomes. The increased benzphetamine-N-demethylase activity can be related to the induction of cytochrome P-450 PB-B.

References

Oct 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L A ReinkeH Rosenberg
Jul 15, 1982·Biochemical Pharmacology·D W Nebert, M Negishi
Jul 30, 1981·Biochemical and Biophysical Research Communications·E Le ProvostJ P Leroux

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Citations

Jan 1, 1987·Pharmacology & Therapeutics·G C Farrell
May 1, 1990·Journal of Gastroenterology and Hepatology·L ZaluznyM Murray
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·John R Cashman, Jun Zhang
Sep 15, 1988·Biochemical Pharmacology·L V Favreau, J B Schenkman

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