PMID: 107506Jan 1, 1979

Immunoradiometric and electroimmuno assay of increased ferritin and apoferritin levels in serum

R D BrownH Kronenberg


Ferritin in serum from patients with increased serum ferritin levels has been studied both quantitatively and qualitatively. All techniques utilized in these studies are suitable to be used as routine screening tests for large numbers of patients. Electroimmuno assay (EIA) has been compared with the solid phase immunoradiometric (IRMA) assay as a technique to determine serum ferritin concentration (r = 0.99) and is suggested as a useful alternative when determining ferritin concentrations above 500 microgram/l. Iron stained EIA gels have been used to indicate the iron content of the ferritin molecule in sera. This simple screening test has demonstrated that apoferritin is found more often than iron-rich ferritin in the serum of patients with elevated serum ferritin levels. Immunoelectrophoresis precipitin bands suggest the heterogeneity of ferritin in serum from different patients.


Mar 8, 1975·British Medical Journal·S HusseinJ F Moorhead
May 1, 1975·The New England Journal of Medicine·A Jacobs, M Worwood
Apr 12, 1975·British Medical Journal·D P Bentley, A Jacobs
Feb 8, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·J W HallidayL W Powell
May 1, 1975·Clinical Science and Molecular Medicine·M WorwoodA Jacobs
Aug 1, 1974·Journal of Clinical Pathology·E A LetskyD M Flynn
Oct 1, 1974·Journal of Clinical Pathology·D P Bentley, P Williams
Sep 1, 1974·Analytical Biochemistry·L E MilesJ D Cook
Sep 1, 1974·British Journal of Haematology·M WorwoodJ A Whittaker
Jun 24, 1971·The New England Journal of Medicine·R R Crichton
Sep 1, 1971·Journal of Clinical Pathology·M R BeamishA Jacobs
Jun 1, 1956·The Journal of Clinical Investigation·K R REISSMANN, M R DIETRICH


Jan 1, 1981·Journal of Biological Standardization·C McLeod, W Katz
Oct 1, 1984·Australian and New Zealand Journal of Medicine·R J TrentH Kronenberg
Dec 1, 1979·British Journal of Haematology·G CaseyR J Kimber
Jan 1, 1983·Pathology·R D BrownH Kronenberg
Feb 1, 1988·European Journal of Haematology·R D BrownH Kronenberg

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