Immunoreactive determinants of CA 125 in women with endometriosis.

Journal of Clinical Pathology
O A MojiminiyiD H Barlow

Abstract

Among 10 patients with endometriosis CA 125 was increased (greater than 35 U/ml) in endometriotic cyst fluid in all the patients, but only two had increased serum concentrations. Gel electrophoresis of serum, endometriotic cyst fluid, and endometriotic tissue resolved the CA 125 immunoreactive fragments from the three sources into bands of similar electrophoretic mobilities. Electrophoresis under reducing and non-reducing conditions showed immunoreactive fragments of apparent masses of 55,000 and 140,000 daltons, respectively. Analysis under reducing conditions did not result in loss of activity. CA 125 antigen is thought to be a high molecular weight glycoprotein complex. As far as is known, this is the first report describing lower molecular weight immunoreactive determinants of CA 125.

References

May 1, 1986·American Journal of Obstetrics and Gynecology·H W de BruijnG J Fleuren
Jun 1, 1986·Fertility and Sterility·P E PattonC B Coulam
Nov 15, 1987·International Journal of Cancer. Journal International Du Cancer·F LeoniM I Colnaghi
Jul 1, 1988·British Journal of Obstetrics and Gynaecology·S H KennedyD H Barlow
Jul 1, 1986·American Journal of Obstetrics and Gynecology·T J O'BrienJ G Quirk
Mar 1, 1987·Histopathology·I A KoelmaG J Fleuren
Sep 15, 1973·Journal of Molecular Biology·F W Studier
Nov 1, 1981·The Journal of Clinical Investigation·R C BastR C Knapp

❮ Previous
Next ❯

Citations

Oct 1, 1994·Clinical Biochemistry·P D WattT England
Aug 10, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Fukunaga
Apr 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·I PhocasP A Zourlas
Sep 1, 1990·American Journal of Obstetrics and Gynecology·D E Pittaway
Aug 1, 1990·British Journal of Obstetrics and Gynaecology·S H KennedyD H Barlow
Nov 3, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Idhaliz FloresCarlos Ríos-Bedoya
Feb 13, 2019·Hormone Molecular Biology and Clinical Investigation·Vitaly B TskhayGyulnar T Mikailly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
C RouxB Amor
Current Opinion in Obstetrics & Gynecology
A el-Roeiy, A A Murphy
© 2022 Meta ULC. All rights reserved