PMID: 6108564Oct 1, 1980Paper

Immunoreactive dynorphin in pituitary and brain

Proceedings of the National Academy of Sciences of the United States of America
A Goldstein, V E Ghazarossian

Abstract

Distribution of the potent opioid peptide dynorphin has been determined in pituitary gland (pig, beef, rat), in the various regions of rat brain, and in rat spinal cord, by using a highly specific antiserum. By gel permeation chromatography in 4 M guanidine, the porcine pituitary immunoreactivity is found in a major peak of apparent molecular weight about 1700 and a minor peak of about 3400. Similar peaks are found in rat pituitary extracts, whereas rat brain contains, in addition, two peaks of larger apparent molecular weight. In the pituitary, immunoreactive dynorphin is found predominantly in pars nervosa. In the central nervous system, it is distributed widely, with highest concentrations in hypothalamus, medulla-pons, midbrain, and spinal cord. Although dynorphin contains leucine-enkephalin, the regional distribution of dynorphin is different from that of enkephalin or of any other known opioid peptide.

References

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Citations

Mar 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·W Knepel, M Schwaninger
Nov 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T SatoA Matsuki
Feb 4, 1982·Brain Research·C GramschA Herz
Jan 22, 1982·European Journal of Pharmacology·T OkaM Wakimasu
Mar 26, 1985·European Journal of Pharmacology·S Spampinato, S Candeletti
Jun 5, 1992·European Journal of Pharmacology·D BouhassiraD Le Bars
Apr 11, 1994·European Journal of Pharmacology·J Q Wang, A J Ingenito
Oct 18, 1982·Life Sciences·J F McGintyF E Bloom
Jan 1, 1983·Life Sciences·C ChavkinF E Bloom
Jan 1, 1983·Life Sciences·D M WrightG Clarke
Mar 1, 1988·Pharmacology, Biochemistry, and Behavior·T D SteeleG K Yim
Jan 1, 1983·Neuropeptides·S Spampinato, A Goldstein
Jan 1, 1983·Pharmacology & Therapeutics·G P KozlowskiE A Zimmerman
Jan 1, 1993·Brain Research. Brain Research Reviews·P W Kalivas
Sep 1, 1995·Brain Research. Brain Research Reviews·W R van FurthJ M van Ree
Nov 1, 1994·Trends in Pharmacological Sciences·V K Shukla, S Lemaire

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