Immunoreactive growth hormone-releasing hormone (IR-GHRH) in the feto-placental circulation and differential effects of L-dopa, L-arginine and somatostatin-14 on the plasma levels of IR-GHRH in normal adults

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
H SaitoS Saito

Abstract

The relation of the physiological releases of growth hormone-releasing hormone (GHRH) and growth hormone (GH) into the circulation in various conditions was investigated using a sensitive and specific radioimmunoassay for plasma GHRH. The mean fasting plasma level of immunoreactive (IR)-GHRH in 72 normal adults was 10.3 +/- 0.5 (mean +/- SEM) pg/ml and there was no significant sex difference in the level. The concentrations of IR-GHRH in plasma from the umbilical artery and umbilical vein were 107.3 +/- 20.5 pg/ml and 33.6 +/- 3.8 pg/ml, respectively, and a marked arterio-venous gradient was observed in all 12 individuals examined. The plasma level of IR-GHRH in the maternal vein was significantly lower than that in the cord blood, but was similar to that in non-pregnant women. In normal adults, although there was no apparent fluctuation in the level of plasma IR-GHRH or of plasma GH during bed rest, a significant increase of plasma IR-GHRH was detected followed by, or synchronized with the surge of plasma GH after oral administration of L-dopa. In contrast, on L-arginine infusion, no proportional elevation of plasma IR-GHRH with increase in plasma GH was observed. During and after intravenous infusion of somatostatin, the circ...Continue Reading

Citations

Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·J KimberC J Mathias
Feb 7, 2020·Nutrients·Vikkie A MustadRicardo Rueda
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Shanshan HanCaroline A Crowther
Apr 13, 2015·The Cochrane Database of Systematic Reviews·Emily BainPhilippa Middleton
Jun 13, 2015·The Cochrane Database of Systematic Reviews·Benja MuktabhantMalinee Laopaiboon
Jun 3, 2015·The Cochrane Database of Systematic Reviews·Erika OtaDiane Farrar

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