PMID: 8587005Jan 1, 1995Paper

Immunoreactive prostate-specific antigen in lung tumors

Journal of Clinical Laboratory Analysis
M LevesqueE P Diamandis

Abstract

Prostate-specific antigen (PSA) is a glycoprotein produced by the epithelial cells of the prostate. PSA is currently used clinically to diagnose and monitor prostate carcinoma. In previous work we have demonstrated that 30% of breast tumors and, more rarely other tumors, contain significant amounts of PSA. PSA appears to be a favorable prognostic indicator in breast cancer. Here, using a sensitive assay, we demonstrated for the first time that lung adenocarcinomas and squamous cell carcinomas also contain PSA. PSA in lung tumor extracts was present mainly in its 33 KDa form (free PSA), at levels measurable by commercial methods. The presence of PSA was associated more closely with male patients and adenocarcinomas. The physiological role of PSA in lung tissue and the prognostic significance of PSA in lung cancer remain to be determined. These and our previous data as well as reports by other groups support the view that PSA is a ubiquitous biochemical marker of steroid hormone action.

References

May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K W WattR Loor
Jan 1, 1994·Breast Cancer Research and Treatment·E P DiamandisD J Sutherland
Jan 1, 1995·Journal of Clinical Laboratory Analysis·M LevesqueE P Diamandis
May 1, 1995·The Journal of Clinical Endocrinology and Metabolism·E P Diamandis, H Yu
Apr 1, 1993·The American Journal of Surgical Pathology·J H van Krieken

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Citations

Jan 1, 1997·Urological Research·N S VerkaikJ C Romijn
Jan 1, 1996·Breast Cancer Research and Treatment·E P DiamandisC López-Otín
Jun 1, 1996·Clinical Biochemistry·D N Melegos, E P Diamandis
May 28, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Alexandra KollaraTheodore J Brown
Apr 7, 2000·Breast Cancer Research and Treatment·M H Black, E P Diamandis
Mar 1, 1997·British Journal of Urology·E P Diamandis
May 1, 1997·The Urologic Clinics of North America·E P Diamandis, H Yu
Oct 6, 1998·Critical Reviews in Clinical Laboratory Sciences·H G RittenhouseA W Partin
Aug 4, 1998·International Journal of Cancer. Journal International Du Cancer·E Corey, M J Corey
Dec 18, 2009·Expert Review of Molecular Diagnostics·Yongliang Yang SAmin I Kassis

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