PMID: 7520846Apr 1, 1994Paper

Immunoreactive prostate-specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age

Clinical Biochemistry
H YuD J Sutherland

Abstract

Prostate-specific antigen (PSA) is believed to be a highly specific marker for normal or cancerous prostatic tissue. We recently found that immunoreactive PSA (IR-PSA) is present in 30% of breast tumor cytosols (from 525 breast cancer patients). In this paper we analyzed a new series of 750 breast tumor cytosols, obtained from 744 women and six men, for IR-PSA. The positivity rates in the old and new series were very similar (approximately 30%). Combining the two series of breast cancer patients, we examined the associations between IR-PSA and estrogen (ER) or progesterone (PR) receptors, or patient age. We found that IR-PSA positivity rate declines with age. PSA-positive tumors were highly associated with either ER-positive or PR-positive tumors alone. However, analysis in a subset of tumors that combine the two receptors, ER(-)/PR(-), ER(+)/PR(-), ER(-)/PR(+), and ER(+)/PR(+), revealed that IR-PSA was only associated with PR, and no relationship was found between IR-PSA and ER. We speculate that the presence of IR-PSA in breast cancer may be associated with the PR action and that the association between PSA and ER is indirect due to the known association between ER and PR. As five of the six male breast tumors were found nega...Continue Reading

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Citations

Jan 1, 1996·Breast Cancer Research and Treatment·F MannelloG Gazzanelli
Jan 1, 1996·Breast Cancer Research and Treatment·E P DiamandisC López-Otín
Jan 1, 1996·Breast Cancer Research and Treatment·H YuC M Croce
Jul 14, 2009·International Journal of Clinical Oncology·Yuko KijimaShoji Natsugoe
Jul 24, 2008·Journal of Cancer Survivorship : Research and Practice·Tal GrenaderLinda Shavit
Jun 1, 1996·Clinical Biochemistry·D N Melegos, E P Diamandis
May 1, 1995·Pharmacology & Therapeutics·E F DicksonE P Diamandis
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·X FilellaL A Rioja
Jan 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·E F DicksonE P Diamandis
Mar 26, 2004·Cancer Detection and Prevention·Edward R SauterEleftherios P Diamandis
Aug 26, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·A MagklaraE P Diamandis
Dec 1, 1996·Clinical Biochemistry·D N MelegosE P Diamandis
Jun 8, 1996·Lancet·L ForetovaF P Li
Mar 27, 1998·Breast Cancer Research and Treatment·Y Oh
Apr 16, 1998·Breast Cancer Research and Treatment·I KoganA M Rauth
Nov 26, 1999·Breast Cancer Research and Treatment·K A AlanenT J Nevalainen
Apr 7, 2000·Breast Cancer Research and Treatment·M H Black, E P Diamandis
Jul 1, 1996·Nature Genetics·E P Diamandis
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Apr 14, 2009·European Heart Journal·Salvatore Patanè, Filippo Marte
Sep 7, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Jaume TrapéUNKNOWN Oncology Section of the Catalan Association of Clinical Laboratory Science
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Jan 6, 2016·The Indian Journal of Surgery·Iqbal SinghR L Tripathi
Feb 3, 2009·International Journal of Cardiology·Salvatore Patanè, Filippo Marte
Jun 1, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Chi-Wai ChengMac-Moune Fernand Lai
May 1, 1997·The Urologic Clinics of North America·E P Diamandis, H Yu
Jul 22, 2008·Cancer Detection and Prevention·Edward R SauterRoger de la Torre

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