PMID: 43589Jan 1, 1979

Immunoreactive secretin release in patients after duodenectomy and partial or total pancreatectomy

Scandinavian Journal of Gastroenterology
L E HanssenS Aune


Seven patients were investigated 8--22 months after duodenectomy and pancreatectomy for chronic pancreatitis or cancer. Seven other patients, admitted for minor surgery, served as controls. 40 ml 100 mmol/l HCl was infused over 5 min into the jejunum 10 cm beyond the gastrojejunal stoma in the duodenectomized patients and 10 cm beyond the pylorus in the controls. Plasma immunoreactive secretin (IRS) increased from 3.0 +/- 0.8 pmol/l (mean +/- S.E.M.) to 9.8 +/- 0.5 pmol/l (p less than 0.01) in the duodenectomized patients. In the controls the increase was significantly higher than in the patients (p less than 0.01)--from 1.5 +/- 0.3 pmol/l to 19.5 +/- 3.3 pmol/l (p less than 0.01). The study shows that the jejunum is able to release IRS after acid infusion in duodenectomized patients.

Related Concepts

Malignant Neoplasm of Jejunum
Secretin Measurement
Malignant Neoplasm of Pancreas
Entire Jejunum
Epilepsies, Partial
Malignant Neoplasm of Pylorus
Surgical Stoma

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