PMID: 6104549Mar 1, 1980Paper

Immunoreactive somatostatin changes during insulin-induced hypoglycaemia and operative stress in man

Clinical Endocrinology
J A WassL H Rees

Abstract

Little is currently known about the factors controlling somatostatin secretion. A radioimmunoassay has been developed that is sufficiently specific and sensitive to be used for physiological studies of circulating levels in man. During insulin-induced hypoglycaemia a rise in plasma somatostatin was seen in each of ten subjects studies. Although this paralleled the rise in circulating glucagon and growth hormone, no individual relationships were found either between these variables or to any change in cortisol or insulin C-peptide. In contrast no rise in somatostatin was seen during surgical stress. Thus, contrary to expectation, circulating somatostatin levels can be altered by metabolic stimuli. It seems likely that this peptide may serve an endocrine as well as a paracrine role since its modulating effects may occur not only near to but also at a distance from the site of secretion. It is not yet clear whether the somatostatin measured comes from the hypothalamus, any other part of the central nervous system or the gastrointestinal tract.

References

Aug 1, 1977·The Biochemical Journal·N OgawaP Brazeau
Mar 1, 1977·Clinics in Endocrinology and Metabolism·A Gomez-Pan, R Hall
Jan 1, 1979·Annals of Clinical Biochemistry·E PenmanL H Rees
Jun 1, 1979·Endocrinology·T YamamotoR H Unger
Sep 1, 1978·Metabolism: Clinical and Experimental·B PrimstoneS Kronheim
Jun 1, 1975·Endocrinology·M BrownsteinJ S Kizer
Nov 1, 1975·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D L HorwitzN Yanaihara
Dec 8, 1973·Lancet·K G AlbertiH Orskov
Jul 24, 1971·British Medical Journal·I A ForsythR P Myres
Apr 1, 1966·The Journal of Clinical Investigation·F C GreenwoodT C Stamp

❮ Previous
Next ❯

Citations

Jun 1, 1982·Regulatory Peptides·L Hilsted, J J Holst
Jun 4, 1981·The New England Journal of Medicine·S MunkgaardB Tronier
Jan 1, 1984·Acta Physiologica Scandinavica·P G BurholJ Florholmen
Jul 1, 1984·Acta Physiologica Scandinavica·P G BurholR Jorde
Apr 1, 1986·Gut·M R Lucey
Nov 1, 1983·Clinics in Endocrinology and Metabolism·A Gómez-Pan, M D Rodriguez-Arnao
Sep 1, 1984·Clinical Endocrinology·S SkareP A Torjesen
Dec 1, 1986·Scandinavian Journal of Gastroenterology·S J Konturek, M E Kitler
Jul 1, 1982·Equine Veterinary Journal·G M HallJ N Lucke
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·V Schusdziarra, R Schmid
Apr 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·O SegersG Somers
Mar 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S WebbJ Rodés
Dec 1, 1983·The American Journal of Physiology·J J HolstO V Nielsen
Jun 1, 1990·Current Problems in Surgery·E MozellT M O'Dorisio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.