Immunoreactive somatostatin in human pancreatic secretion

The Journal of Clinical Endocrinology and Metabolism
A ErtanA Arimura

Abstract

Somatostatin in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography following secretin injection was determined by RIA. The mean immunoreactive somatostatin (IRS) levels in the pancreatic juice of 13 non-diabetics was 78 +/- 11 (SE) pg/ml. The IRS levels in 4 non-insulin-dependent diabetics ranged from 843 to 2286 pg/ml with a mean of 1559 +/- 392 (SE) pg/ml. This was significantly greater than non-diabetic values. The IRS in the pancreatic juice was immunologically indistinguishable from somatostatin14 but consisted of 2 major components, one corresponding to somatostatin14 and the other being of a molecular size of approximately 3000 daltons.

Citations

Jul 1, 1984·Digestive Diseases and Sciences·A ErtanJ Ryan
Jan 1, 1981·Peptides·A ArimuraA I Vinik
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Eugenio Bertelli, Moïse Bendayan
Jan 1, 1989·Acta Oncologica·H Olsson
Dec 1, 1989·Scandinavian Journal of Gastroenterology·M GuidetA Ribet
Aug 1, 1987·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·P M Pour, R E Hauser

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