Immunoreactive substance P in the chicken gut: distribution, development and possible functional significance

Cell and Tissue Research
E BrodinF Sundler

Abstract

The distribution and cellular localization of substance P in the chicken gut was studied by immunocytochemistry and immunochemistry. Substance P-containing nerve fibers are numerous in the gut wall. They occur in the smooth muscle layer as well as in the mucosa, where they are associated with blood vessels or surround the intestinal crypts. The fibers are particularly numerous in the myenteric and submucosal plexuses, where substance P-containing nerve-cell perikarya are also encountered. Substance P was found also in scattered endocrine cells of the small intestine, caeca and colon. Previously, bombesin-containing cells, which are numerous in the proventriculus, have been mistakenly identified as substance P cells due to cross-reactivity of certain antisera against substance P. Immunochemistry revealed the highest concentration of substance P differs slightly from that of synthetic bovine substance P, suggesting that chicken substance P differs structurally from mammalian substance P. Substance P-containing nerve fibers in the chicken gut develop slowly after hatching, apparently beginning in the duodenum; at approximately 20 weeks after hatching the distribution pattern is fully developed. A functional investigation was perfo...Continue Reading

Citations

Mar 1, 1988·Cell and Tissue Research·A RésiboisR Pochet
Jan 1, 1983·Archives of Oto-rhino-laryngology·R UddmanF Sundler
Jan 1, 1982·Archives of Oto-rhino-laryngology·R UddmanF Sundler
Aug 1, 1989·Digestive Diseases and Sciences·E EkbladF Sundler
Jun 1, 1987·World Journal of Surgery·H MårtenssonA Nobin
Mar 1, 1985·Regulatory Peptides·S AggestrupH R Sørensen
Feb 1, 1988·Regulatory Peptides·J M ConlonL Thim
Jan 1, 1985·Peptides·S Holmgren
Oct 1, 1983·Neuroscience·E MoghimzadehF Sundler
Jan 1, 1987·Neuroscience·E EkbladF Sundler
Nov 1, 1988·Neuroscience·E EkbladF Sundler
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S Nilsson, S Holmgren
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S Holmgren
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J Jensen, S Holmgren
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C W Bowers, L M Dahm
Jan 1, 1982·Acta Physiologica Scandinavica·E BrodinK Folkers
Aug 1, 1982·Acta Physiologica Scandinavica·S LeanderR Uddman
Dec 1, 1986·Digestive Diseases and Sciences·S AggestrupP Emson
Jan 1, 1989·Veterinary Research Communications·V De SaedeleerA Houvenaghel
Aug 21, 2010·Autonomic Neuroscience : Basic & Clinical·Catharina Olsson, Susanne Holmgren
Feb 1, 1990·Scandinavian Journal of Gastroenterology·J PerssonP H Magnusson
Mar 1, 1983·The Annals of Otology, Rhinology, and Laryngology·R UddmanF Sundler
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R UddmanF Sundler
Dec 1, 1981·Cephalalgia : an International Journal of Headache·L Edvinsson, R Uddman
Dec 1, 1984·The Journal of Experimental Zoology·B B Rawdon
Dec 1, 1984·Japanese Journal of Pharmacology·S KomoriH Ohashi

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