PMID: 7536507Nov 1, 1994Paper

Immunoreactive tenascin in tumours of salivary glands: evidence for enhanced expression in tumour stroma and production by tumour cells

European Journal of Cancer. Part B, Oral Oncology
P ShresthaM Mori

Abstract

Tenascin, a large molecular weight extracellular glycoprotein expressed at the epithelial-mesenchymal interface during morphogenesis in embryo, wound healing and in the stroma of various benign and malignant tumours was evaluated in a series of primary epithelial tumours of salivary glands using a monoclonal antibody. Normal salivary glands (n = 5) had linear delicate band-like immunoreactive tenascin in relatively large excretory or intralobular ducts. Pleomorphic adenomas (n = 40) had heterogeneity of expression in modified myoepithelial cell-associated myxoid, hyaline and chondroid areas. Warthin's tumours (n = 10) had a linear immunoreactivity profile of tenascin just adjacent to the basal cells of the epithelial tumour component. A heterogeneity of expression with intense to low or negative stromal immunoreactivity was observed in adenoid cystic carcinomas (n = 8), mucoepidermoid carcinomas (n = 8), epithelial-myoepithelial carcinomas (n = 4), polymorphous low-grade carcinomas (n = 3), papillary cystadenocarcinomas (n = 15) and undifferentiated carcinomas (n = 3). In addition, small cystic spaces or lumens of epithelial-lined tubulo-ductal structures in numerous salivary tumours had positive immunoreactivity for tenascin, ...Continue Reading

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Citations

Sep 4, 2010·Cancer Metastasis Reviews·David S GutteryRosemary A Walker
May 12, 2011·Head and Neck Pathology·Apostolos EpivatianosAnastasios Markopoulos
May 1, 1995·European Journal of Cancer. Part B, Oral Oncology·S K LeeM Mori
Jul 1, 1995·European Journal of Cancer. Part B, Oral Oncology·M MoriP Shrestha
Mar 1, 1996·European Journal of Cancer. Part B, Oral Oncology·P ShresthaM Mori
Nov 19, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shuichi Fujita, Tohru Ikeda
Apr 16, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·R RaitzV C Araújo
Jun 1, 2006·Journal of Applied Oral Science : Revista FOB·Patrícia Meira BentoLélia Batista de Souza
Jan 9, 2004·Oncogene·Marianne L VozWim J M Van de Ven
Dec 20, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Vera Cavalcanti de AraújoNey Soares de Araújo
Feb 8, 2005·Oral Oncology·Trent H WesternoffBrian L Schmidt

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