PMID: 6159294May 1, 1980Paper

Immunoreactive trypsins in sera from dogs before and after induction of experimental pancreatitis

Hoppe-Seyler's Zeitschrift für physiologische Chemie
A Borgström, K Ohlsson

Abstract

Radioimmunoassays for anionic and cationic dog trypsins are described. Characterization of the immunoreactivities in sera from fasting dogs demonstrated the presence of the two proenzymes only. Fasting sera from 10 dogs contained anionic and cationic trypsinogen in concentrations between 17-110 micrograms/l and 7-19 micrograms/l, respectively. Induction of experimental pancreatitis in dogs was accompanied by a large increase of immunoreactive anionic and cationic trypsins in the circulation. During the progress of the pancreatitis, immunoreactive trypsin with larger molecular weight than trypsinogen appeared. This high molecular weight immunoreactive trypsin was not seen in serum after intravenous injection of pancreatic juice in dogs. The high molecular weight immunoreactive trypsin probably consists of trypsin in complex with protease inhibitors. In vitro studies showed that the immunoreactivity of trypsin decreased considerably after binding to alpha 1-antitrypsin or alpha-macroglobulins.

References

Dec 1, 1978·European Journal of Clinical Investigation·A Borgström, K Ohlsson
May 1, 1979·Hoppe-Seyler's Zeitschrift für physiologische Chemie·A Borgström
Dec 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·A Borgström, K Ohlsson
May 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·C B Laurell
Dec 28, 1971·Biochimica Et Biophysica Acta·J I Thorell, B G Johansson

❮ Previous
Next ❯

Citations

Jul 18, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·C FabrisG Ceriotti
Jul 26, 2000·Journal of the American Veterinary Medical Association·N C SwiftC R Norris
Aug 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·P JönssonK Ohlsson
Dec 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·A BorgströmK Ohlsson
Apr 15, 1999·The Veterinary Clinics of North America. Small Animal Practice·J M Steiner, D A Williams
Jan 1, 1981·Scandinavian Journal of Gastroenterology·A Borgström

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.