Immunoreactivity against Goblet cells in patients with inflammatory bowel disease

Inflammatory Bowel Diseases
Brita ArdesjöOlov Ekwall

Abstract

A number of autoantibodies have been reported in inflammatory bowel disease (IBD). The aim of this study was to investigate to what extent sera from patients with IBD contain autoantibodies directed against normal human gastrointestinal mucosa. Samples of sera from 50 patients with IBD and 50 healthy subjects were used for immunostaining of normal and affected human gastrointestinal tissues. Eighty-four percent of the sera from IBD patients showed immunoreactivity against goblet cells in the appendix compared with 8% of the sera from healthy subjects. Goblet cell reactivity of IBD patient sera varied between regions in the gastrointestinal tract. Sera from healthy subjects only reacted with goblet cells in the appendix. In the colon and the appendix, goblet cell reactivity of IBD sera was generally weak at the base of the crypts and gradually increased toward the lumen. Three IBD sera samples reacted with gastrin cells in the antrum. In colon biopsies from patients with ulcerative colitis, immunoreactivity against the remaining goblet cells showed an inverse correlation with inflammatory activity. These findings suggest that immunoreactivity against goblet cells may be of central importance in the pathogenesis of IBD. Identific...Continue Reading

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Citations

May 10, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Daniel LaubitzFayez K Ghishan
Nov 13, 2009·World Journal of Gastroenterology : WJG·Krzysztof FyderekPiotr B Heczko
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Oct 16, 2009·European Journal of Gastroenterology & Hepatology·Brita Ardesjö LundgrenOlov Ekwall

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