Immunoreactivity of neurogenic factor in the guinea pig brain after prenatal hypoxia

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
Yoonyoung ChungYonghyun Jeon

Abstract

Chronic prenatal hypoxia is considered to cause perinatal brain injury. It can result in neurological disorders such as cerebral palsy or learning disabilities. These neurological problems are related to chronic placental insufficiency (CPI), which leads to chronic hypoxemia and hypoglycemia. The effects of hypoxia on neurogenesis during development have been a matter of controversy. We therefore investigated the effect of chronic prenatal hypoxia in the brain of the fetal guinea pig using the guinea pig CPI model. Chronic placental insufficiency was induced by unilateral uterine artery ligation at 30-32 days of gestation (dg: with term defined as ∼67dg). At 50 and 60dg, fetuses were sacrificed and assigned to either the growth-restricted (GR) or control (no ligation) group. Immunohistochemistry was performed with HIF-1α, PCNA, NeuN and BDNF antibodies in the cerebral cortex and dentate gyrus. The number of NeuN-IR and BDNF-IR cells was lesser in GR fetuses than in controls in the cerebral cortex and dentate gyrus at 60dg (p<0.05). The growth of the developing brain is dependent upon the availability of growth factors such as BDNF. The reduction in the number of neuronal cells observed in our GR group was associated with the ob...Continue Reading

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Citations

Oct 1, 2016·Journal of Developmental Origins of Health and Disease·H DickinsonJ L Morrison
Oct 5, 2018·Physiology International·R IndriawatiG Partadiredja
Dec 5, 2018·Frontiers in Neuroscience·Natalia N NalivaevaIgor A Zhuravin
Oct 17, 2018·The Journal of Physiology·Sebastian QuezadaMary Tolcos
Feb 26, 2021·Experimental Neurology·Diego Bulcão ViscoRaul Manhães-de-Castro

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