Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients.

Respiratory Research
Els BeijerMarcel Veltkamp

Abstract

Involvement of metals or silica in the pathogenesis of sarcoidosis has been suggested by several case reports and specific epidemiological studies. However, the combination of occupational exposure and an immunological reaction has not been studied before in a group of sarcoidosis patients and non-sarcoidosis controls. In 256 sarcoidosis patients and 73 control patients with obstructive sleep apnea, exposure to metal and silica was assessed using a questionnaire consisting of a complete occupational history subsequently linked to job-exposure matrices. Next, immunoreactivity to aluminium, beryllium, zirconium and silica was determined in 33 sarcoidosis and 19 control patients using a lymphocyte proliferation test. In sarcoidosis, 83 out 256 patients (32.4%) had occupational exposure to metals or silica, compared to 24.7% in the control group (p = 0.21). A significantly higher percentage of the sarcoidosis patients tested showed immunoreactivity to metals or silica compared to the control group (21.2 and 0% respectively, p = 0.039). Immunoreactivity to silica and metals was only found in sarcoidosis patients, supporting the hypothesis that these antigens may be involved in the pathogenesis of a distinct subgroup of sarcoidosis p...Continue Reading

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Citations

Jun 9, 2021·Chest·L Christine Oliver, Andrew M Zarnke
Aug 3, 2021·Internal Medicine·Yasutaka MochizukaHidenori Nakamura
Aug 17, 2021·Respiratory Medicine·Nancy W LinLi Li
Jun 28, 2021·Current Opinion in Pulmonary Medicine·Els Beijer, Marcel Veltkamp
Oct 27, 2021·Current Opinion in Pulmonary Medicine·Nancy W Lin, Lisa A Maier

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BETA
X-ray
biopsy

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MELISA®
DOM JEM
REDCap

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